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It had been demonstrated that potassium channels played a key role in regulating neuronal excitability, which was closely associated with neurological diseases including epilepsy, ataxia, myoclonus, and psychiatric disorders. In recent years, a growing body of evidence from whole\u2010genome sequencing and whole\u2010exome sequencing had identified several ASD susceptibility genes of potassium channels in ASD subjects. Genetically dysfunction of potassium channels may be involved in altered neuronal excitability and abnormal brain function in the pathogenesis of ASD. This review summarizes current findings on the features of ASD\u2010risk genes (<jats:italic>KCND2, KCNQ2, KCNQ3, KCNH5, KCNJ2, KCNJ10<\/jats:italic>, and <jats:italic>KCNMA1<\/jats:italic>) and further expatiate their potential role in the pathogenicity of ASD.<\/jats:p>","DOI":"10.1002\/jdn.10123","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T04:01:22Z","timestamp":1621396882000},"page":"479-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Potassium channels and autism spectrum disorder: An overview"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8831-4650","authenticated-orcid":false,"given":"Peipei","family":"Cheng","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience State Key Laboratory of Neuroscience Key Laboratory of Primate Neurobiology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences  Shanghai China"},{"name":"Shanghai Center for Brain Science and Brain\u2010Inspired Intelligence Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasong","family":"Du","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1971.tb06990.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.154336"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1667"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fncel.2018.00076","article-title":"A novel KCNJ2 mutation identified in an autistic proband affects the single channel properties of Kir2.1","volume":"12","author":"Binda A.","year":"2018","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00088.2009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2516-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2667-06.2006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-23"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2012.01838.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1585"},{"key":"e_1_2_8_14_1","first-page":"2959","article-title":"Lipopolysaccharides increase Kir2.1 expression in lung endothelial cells","volume":"11","author":"Fang W.","year":"2018","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324574"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116521"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00054"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6661-10.2011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05012.2003"},{"issue":"1","key":"e_1_2_8_20_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.65","article-title":"Fragile X syndrome","volume":"3","author":"Hagerman R. 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