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We aimed to evaluate the brain water content, the blood\u2013brain barrier permeability, and the expression of aquaporin 1 and 4, and GFAP in a valproic acid\u2010animal model, assessing the effect of resveratrol. On postnatal day 30, Wistar rats of the valproic acid group showed greater permeability of the blood\u2013brain barrier to the Evans blue dye and a higher proportion of brain water volume, prevented both by resveratrol. Prenatal exposition to valproic acid diminished aquaporin 1 in the choroid plexus, in the primary somatosensory area, in the amygdala region, and in the medial prefrontal cortex, reduced aquaporin 4 in medial prefrontal cortex and increased aquaporin 4 levels in primary somatosensory area (with resveratrol prevention). Valproic acid exposition also increased the number of astrocytes and GFAP fluorescence in both primary somatosensory area and medial prefrontal cortex. In medial prefrontal cortex, resveratrol prevented the increased fluorescence. Finally, there was an effect of resveratrol <jats:italic>per se<\/jats:italic> on the number of astrocytes and GFAP fluorescence in the amygdala region and in the hippocampus. Thus, this work demonstrates significant changes in blood\u2013brain barrier permeability, edema formation, distribution of aquaporin 1 and 4, in addition to astrocytes profile in the animal model of autism, as well as the use of resveratrol as a tool to investigate the mechanisms involved in the pathophysiology of autism spectrum disorder.<\/jats:p>","DOI":"10.1002\/jdn.10137","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T01:59:36Z","timestamp":1625191176000},"page":"579-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Resveratrol prevents brain edema, blood\u2013brain barrier permeability, and altered aquaporin profile in autism animal model"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-1938","authenticated-orcid":false,"given":"Iohanna","family":"Deckmann","sequence":"first","affiliation":[{"name":"Translational Research 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