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The hippocampus which is involved in learning and memory is highly susceptible to the ethanol neurotoxic effects. Oxidative stress is one of the mechanisms in alcohol\u2010induced disorders. Ethanol also interferes with the brain\u2010derived neurotrophic factors (BDNF) expression. Using vitamin E as a potent antioxidant, we studied the possible interrelation between oxidative stress and BDNF on cognition. Ethanol (4\u2009g\/kg) and vitamin E (100, 200, and 400\u2009mg\/kg) were given to pregnant Wistar rats on first day of gestation (GD) until weaning (28\u2009days). Oxidative stress marker, BDNF expression, and cyclic AMP\u2010response binding\u2010protein (CREB) expression levels were measured on postnatal days (PND) 28. Object location memory (OLM) was evaluated on PND 34. Our results demonstrated that ethanol exposure significantly reduced glutathione peroxidase (GPx) activity, reduced glutathione (GSH), reduced\/oxidized glutathione (GSH\/GSSG) ratio, and increased superoxide dismutase (SOD) activity, malondialdehyde (MDA) levels, and carbonyl protein content in the hippocampus. Total BDNF, BDNF mRNA, and CREB expression significantly reduced in the hippocampus by ethanol exposure. Also, ethanol significantly reduced the discrimination index (DI) in the OLM test. In addition, vitamin E administration could reduce oxidative stress, increase significantly BDNF and CREB levels, and improve cognitive dysfunction induced by ethanol exposure. Collectively, results suggest that probably oxidative stress can interrelate with the BDNF system for modulating cognitive function in the ethanol\u2010exposed rat.<\/jats:p>","DOI":"10.1002\/jdn.10148","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T14:09:29Z","timestamp":1629814169000},"page":"717-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal ethanol exposure induces behavioral deficits through oxidative stress and brain\u2010derived neurotrophic factor interrelation in rat offspring"],"prefix":"10.1002","volume":"81","author":[{"given":"Rahebeh","family":"Mahdinia","sequence":"first","affiliation":[{"name":"School of Biology Damghan University  Damghan 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