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The objective of the present study was to verify the effect of 6\u2010shogaol on behavioral parameters in a preclinical model based on a maternal immune activation (MIA) by lipopolysaccharide (LPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Twelve pregnant Wistar rats received 100\u2010\u03bcg\/kg LPS or saline solution on gestational day (GD) 9.5. Male offspring participated in the study and in the postnatal day (PND) 30 and 55 were supplemented with 6\u2010shogaol or saline solution, by gavage at a dose of 10\u00a0mg\/kg\/day, orally for 5\u00a0days. In the PND 35 and 60 was performed the behavioral tests: grooming, crossing, and rearing that evaluated repetitive movements, anxiety, and interest in the new, respectively, and the inhibitory avoidance test that evaluated short\u2010term (STM) and long\u2010term memory (LTM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Prenatal exposure to LPS increased the grooming and crossing episodes at different ages and reduced rearing episodes in PND 37. Treatment with 6\u2010shogaol reversed these parameters. In the inhibitory avoidance test, an improvement of memory was identified with 6\u2010shogaol in the STM and LTM at both ages comparing training and test session of treated groups and between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of 6\u2010shogaol reverses the stereotypy, exploratory behavior, and memory impairment in prenatal LPS\u2010exposed offspring, acting as a promising therapeutic component against brain disorders associated with the process of MIA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10157","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T03:54:42Z","timestamp":1636516482000},"page":"39-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["6\u2010Shogaol improves behavior and memory in Wistar rats prenatally exposed to lipopolysaccharide"],"prefix":"10.1002","volume":"82","author":[{"given":"Naiana","family":"da Rosa","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Durante","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-8443","authenticated-orcid":false,"given":"Ana Ol\u00edvia Martins","family":"Laurentino","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Medeiros","family":"Peretti","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-0501","authenticated-orcid":false,"given":"Richard Simon","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juc\u00e9lia Jeremias","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-2808","authenticated-orcid":false,"given":"Fabr\u00edcia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit University of Southern Santa Catarina (UNISUL)  Tubar\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Manual Diagn\u00f3stico e Estat\u00edstico de Transtornos Mentais","author":"American Psychological Association","year":"2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-012-1552-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2225-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00058"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.08.007"},{"key":"e_1_2_9_7_1","first-page":"807","volume-title":"Farmacologia Aplicada \u00e0 Medicina Veterin\u00e1ria","author":"Bernardi M. 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