{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:45:43Z","timestamp":1774460743444,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this systematic review was to explore and discuss the literature concerning the effects of hypoxia or anoxia during the perinatal period on the serotoninergic network in rodents, through mechanisms that lead to changes in serotonergic neurons, levels, segments of central nervous system affected, 5\u2010HT transporter, and 5\u2010HT receptor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature searches were performed in Embase, Medline (PubMed), Web of Science, and SCOPUS, from April to July 2021, with a total of 1045 published studies found. Using a predefined protocol, as registered on the CAMARADES website, 10 articles were included in this review. The PRISMA statement was used for reporting this systematic review. The internal validity was assessed using the SYRCLE's risk of bias tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our main findings show that hypoxia in the first days of postnatal life led to a disturbance in the serotonergic system with reduced in 5\u2010HT fibers, reduced brain levels of 5\u2010HT and 5\u2010HIAA, reduced SERT protein expression, and reduced receptor 5\u2010HT<jats:sub>7<\/jats:sub>. Putative mechanisms involving damage in the serotoninergic system include retrograde cell death resulting from primary damage mainly in forebrain areas, which impairs remote areas including serotonergic raphe nuclei. Other probable mechanisms associated with the serotoninergic network damage may be triggered by excitotoxic lesion and neuroinflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypoxia at the beginning of an animal's life leads to modification of the serotonergic components associated with putative mechanisms that include cell damage and neuroinflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10226","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T06:28:01Z","timestamp":1661236081000},"page":"667-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serotonergic mechanisms associated with experimental models of hypoxia: A systematic review"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-1029","authenticated-orcid":false,"given":"Isadora Braga Contreiras","family":"Carneiro","sequence":"first","affiliation":[{"name":"Center for Biological and Health Sciences Federal University of Western Bahia. Estrada da Prainha s\/n  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Elisa","family":"Toscano","sequence":"additional","affiliation":[{"name":"Nursing Unit, Vit\u00f3ria Academic Center Federal University of Pernambuco  Vit\u00f3ria de Santo Ant\u00e3o PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela de S\u00e1 Barreto","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences Federal University of Western Bahia. Estrada da Prainha s\/n  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Cabral","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Health Sciences Center Federal University of Para\u00edba  Jo\u00e3o Pessoa PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Brielle","family":"Pontes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco  Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Manh\u00e3es","family":"de Castro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nutrition Federal University of Pernambuco  Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Cristina Bonfim","family":"de Jesus Deir\u00f3","sequence":"additional","affiliation":[{"name":"Department of Nutrition Federal University of Bahia  Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairza Maria Barreto","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition Federal University of Bahia  Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00614-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020210"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/650382"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.08.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420420"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00250"},{"key":"e_1_2_10_8_1","first-page":"315","volume-title":"The biochemical basis of neuropharmacology","author":"Cooper J. R.","year":"1986"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90070-R"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Fernstrom J. D.(1991).Effects of the diet and other metabolic phenomena on brain tryptophan uptake and serotonin synthesis(pp.369\u2013376).https:\/\/doi.org\/10.1007\/978-1-4684-5952-4_34","DOI":"10.1007\/978-1-4684-5952-4_34"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1256"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb01914.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00046"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165850"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1111"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.07.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1626-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00417"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010056"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328125"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70141-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1695360"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.09.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(82)90077-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a9ef34"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.13"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-014-0079-z"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20240"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(96)00007-X"},{"key":"e_1_2_10_33_1","first-page":"565","volume-title":"Handbook of Behavioral Neuroscience","author":"Oades R.","year":"2009"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4545-5"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.266067"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08276.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.06.016"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.065"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.068"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90146-9"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111688"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1535-7597.2003.03508.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113643"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.04.003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471509"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3182020b7b"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2012.04.002"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2473-3"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00691-X"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.10226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jdn.10226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.10226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:02:23Z","timestamp":1692547343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jdn.10226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jdn.10226"],"URL":"https:\/\/doi.org\/10.1002\/jdn.10226","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2022-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}