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Indole\u20103\u2010carbinol (I3C) has shown neuroprotective effects in some disease conditions. However, the neuroprotective role of I3C in neonatal anoxia has not been explored. Consequently, we have investigated the effect of I3C on neonatal anoxia\u2010induced brain injury and neurodevelopmental deficits. Rat pups after 30\u2009h of birth were subjected to two episodes of anoxia (10\u00a0min in each) at a time interval of 24\u2009h by flowing 100% nitrogen. I3C was administered within 30\u2009min of the second episode of anoxia on a postnatal day (PND) 3 and continued for PND 9. Neurodevelopmental deficits, cortical mitochondrial membrane potential (MMP), opening of mitochondrial permeability transition pore (MPTP), electron transport chain (ETC) enzyme activities, oxidative stress, hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) levels, histopathological changes, and apoptosis were measured. I3C treatment dose\u2010dependently ameliorated the neurodevelopmental deficits and somatic growth in anoxic pups. I3C improved mitochondrial function by enhancing the MMP, mitochondrial ETC enzymes, and antioxidants. It blocked the MPTP opening and release of cytochrome C in anoxic pups. Further, I3C reduced the elevated cortical HIF\u20101\u03b1 in neonatal anoxic pups. Furthermore, I3C ameliorated histopathological abnormalities and mitochondrial\u2010mediated apoptotic indicators Cyt C, caspase\u20109, and caspase\u20103. Our study concludes that I3C improved neuronal development in anoxic pups by enhancing mitochondrial function, reducing HIF\u20101\u03b1, and mitigating apoptosis.<\/jats:p>","DOI":"10.1002\/jdn.10234","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T05:44:57Z","timestamp":1666158297000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Indole\u20103\u2010carbinol ameliorated the neurodevelopmental deficits in neonatal anoxic injury in rats"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-1410","authenticated-orcid":false,"given":"Kakarla","family":"Ramakrishna","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology Banaras Hindu University (IIT BHU)  Varanasi India"},{"name":"Department of Pharmacy Koneru Lakshmaiah Education Foundation  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