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Studies showed that obesity\u2010induced oxidative stress contributes to the genesis of neurological diseases through dysregulation of the brainstem and hypothalamus. Fluoxetine (Fx) is an antidepressant member in the family of selective serotonin reuptake inhibitors (SSRI) that can induce positive effects by reducing oxidative damage in brain tissues. We aimed to evaluate the late effect of Fx in the brainstem and hypothalamus of overnourished rats during development. Male Wistar rats, after birth, were randomly divided into the normal\u2010nourished group (N, <jats:italic>n<\/jats:italic>\u2009=\u20099) and the overnourished group (O, <jats:italic>n<\/jats:italic>\u2009=\u20093). On the 39th day of life, the groups were subdivided into normofed, and the overnourished group treated or not with fluoxetine (10\u2009mg\/kg daily) (NF, NV, OF, and OV). 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