{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:18:58Z","timestamp":1790716738022,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Morphological differences that can lead to cerebellar volume changes are associated with the pathogenesis of paediatric diseases. The aim of this study was to examine cerebellum volume in a healthy paediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>To provide MRI\u2010based volumetric measurements of the cerebellum, images from the years 2019 to 2021 were scanned retrospectively. A total of 100 images, including the paediatric population aged 0\u201315\u2009years, were imported into the volBrain software. Volumetric segmentations were obtained automatically, and each lobular cerebellar volume was obtained. The samples were divided into groups of 0\u20132\u00a0years (<jats:italic>n<\/jats:italic>\u2009=\u200918), 3\u20135\u00a0years (<jats:italic>n<\/jats:italic>\u2009=\u200924), 6\u201311\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u200934) and 12\u201315\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u200924). Obtained cerebellar volumes, age groups, gender and bilateral side comparisons were made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the comparative analyses performed for the total cerebellum and each of the 12 lobular segments, statistically significant differences were found between the age groups in all measurements except Crus II, lobules VIIB, VIIIA and VIIIB (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In multiple comparison tests, statistically significant differences were found between defined age groups, especially infants and toddlers and early adolescence groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There was a significant positive correlation between the ages of the subjects and their cerebellum volumes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Statistically significant differences were found in lobules I\u2013II, VI, VIIIB, IX and X in right and left side volumes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a tendency to increase in cerebellar volume during the transition from childhood to adolescence. The cerebellum has volumetric differences in the first years of life and during adolescence. When the development of a healthy cerebellum is analysed based on volumetric segmentation, differences are observed. The findings of this study may be useful in confirming various theories attributed to the cerebellum in the clinic.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10259","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T06:25:29Z","timestamp":1681971929000},"page":"323-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Automatic segmentation of the cerebellum using volBrain software in normal paediatric population"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-483X","authenticated-orcid":false,"given":"Ozan","family":"Turamanlar","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Izmir K\u00e2tip Celebi University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-9940","authenticated-orcid":false,"given":"Yunus Emre","family":"Kundakci","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-1936","authenticated-orcid":false,"given":"Alperen","family":"Saritas","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-9542","authenticated-orcid":false,"given":"Abd\u00fclkadir","family":"Bilir","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-1183","authenticated-orcid":false,"given":"Emre","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-1735","authenticated-orcid":false,"given":"Cigdem Ozer","family":"G\u00f6kaslan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.646052"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.06.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0312-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2008.01.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.4.551"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-018-9408-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1638"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.12.1663"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2168479019856572"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2003.09.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807309235"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24346"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3479-08.2008"},{"key":"e_1_2_10_16_1","first-page":"65","article-title":"Determination of cerebellar volume in children and adolescents with magnetic resonance images","volume":"71","author":"Kosar M. 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