{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:21:26Z","timestamp":1788481286233,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms including impairment in social communication and restrictive and repetitive behaviors and interests. Music has emerged in the past decade as an intervention therapy for children with ASD. The aim of the present study was to evaluate the effects of music on cognition impairments in the valproic acid (VPA) rat model of autism. The VPA was administered for animal modeling of autism on embryonic day 12.5 (E12.5) (600\u2009mg\/kg). Male and female pups were sub divided into four main groups (Saline.Non\u2010music, VPA.Non\u2010music, Saline.Music, and VPA.Music). The rats in the music groups were exposed to Mozart's piano sonata K.448 for 30\u2009days (4\u00a0h\/day), from postnatal day (PND) 21 to 50. Autistic\u2010like behaviors were tested using a social interaction, the Morris water maze (MWM), and a passive avoidance tasks at the end of the PND 50. Our results demonstrated that VPA\u2010exposed rat pups had significantly lower sociability and social memory performance compared with the saline\u2010exposed rats in both sexes. VPA\u2010exposed rat pups exhibited learning and memory impairments in the MWM and passive avoidance tasks. Our results demonstrated that music improved sociability in VPA\u2010exposed rats, especially in males. Furthermore, our findings revealed that music improved learning impairments in VPA\u2010exposed male rats in MWM task. In addition, music improved spatial memory impairments in VPA\u2010exposed rats of both sexes. We also found that music improved passive avoidance memory impairments in VPA\u2010exposed rats of both sexes, especially in females. More investigation in future studies are needed.<\/jats:p>","DOI":"10.1002\/jdn.10260","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T05:29:28Z","timestamp":1685338168000},"page":"399-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Music alleviates cognitive impairments in an animal model of autism"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-4466","authenticated-orcid":false,"given":"Farahnaz","family":"Taheri","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Joushi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadijeh","family":"Esmaeilpour","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"},{"name":"Physics and Astronomy department University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Sheibani","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Navid","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Taheri Zadeh","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1525\/mp.2010.27.4.251"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01307-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20356"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/act.2013.19510"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00621.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2724"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9478"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607860601086504"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.02.009"},{"key":"e_1_2_11_11_1","volume-title":"Findings and conclusions: National standards project, phase 2","author":"Center N. A.","year":"2015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10050274"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3927"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2011.00109"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00489"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S117499"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463-1741.153402"},{"issue":"1","key":"e_1_2_11_18_1","article-title":"Epidemiological controversies in autism","volume":"171","author":"Fombonne E.","year":"2020","journal-title":"Swiss Archives of Neurology, Psychiatry and Psychotherapy"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.03.034"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.06.019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/pmu0000033"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1893"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001957"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1938"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.17.3.439"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2336-y"},{"key":"e_1_2_11_27_1","first-page":"28","article-title":"Keys to success with autistic children: Structure, predictability, and consistency are essential for students on the autism Spectrum","volume":"16","author":"Iseminger S. H.","year":"2009","journal-title":"Teaching Music"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10066"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03306.2002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.05.008"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0566-6"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2018.01.011"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.10.007"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1632638.319"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034819"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.012"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19418-7"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14435"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.05.020"},{"key":"e_1_2_11_40_1","first-page":"4","article-title":"The effects of background music on the executive function of children with ADHD in the classroom setting: A study proposal","volume":"10","author":"Mittag J.","year":"2020","journal-title":"Occam's Razor"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110356"},{"key":"e_1_2_11_42_1","unstructured":"Organization W. H.(2017).Autism spectrum disorders: Fact sheet. Retrieved on May 21 2017."},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364873"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106539"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/08098130903377399"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110783"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2006.02.009"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06155-z"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569543.2017.1344711"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.10.2.1104.1"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035885"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(08)16"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.15547\/tjs.2019.03.002"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.04.010"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03554-8"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.01.009"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.005"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.07.018"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.110"},{"key":"e_1_2_11_60_1","first-page":"47","article-title":"Enhancement of spatial learning\u2010memory in developing rats via Mozart music","volume":"7","author":"Yao J.\u2010G.","year":"2009","journal-title":"Journal of Electronic Science and Technology"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.17795\/ijpbs-3483"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.10260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:11:02Z","timestamp":1692231062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jdn.10260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,28]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/jdn.10260"],"URL":"https:\/\/doi.org\/10.1002\/jdn.10260","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,28]]},"assertion":[{"value":"2022-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}