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Investigations of protective agents, which could prevent the adverse outcomes of prenatal stress (PS), are warranted. Agmatine is a neurotransmitter putatively involved in the physiological response to stress, and exogenous administration of agmatine has been shown to produce a variety of neuroprotective effects. In this study, we aimed to assess whether prenatal agmatine exposure could ameliorate behavioural and cognitive deficits in female offspring born to prenatally stressed mice. Pregnant Swiss Webster (SW) mice were exposed to physical or psychological stress from the 11th to 17th days of gestation. Agmatine (37.5\u2009mg\/kg, i.p.) was administrated 30\u2009min before the induction of stress for seven consecutive days. The pups were assessed using a variety of behavioural tests and molecular assays on postnatal days 40 to 47. Agmatine attenuated impairments in locomotor activity, anxiety\u2010like behaviour, and drug\u2010seeking behaviour associated with both physical and psychological PS. Furthermore, agmatine reduced PS\u2010induced impairments in passive avoidance memory and learning. Neither PS nor agmatine treatment affected the mRNA expression level of hippocampal brain\u2010derived neurotrophic factor (BDNF) or tyrosine hydroxylase (TH) in the ventral tegmental area (VTA). Taken together, our findings highlight the protective effects of prenatally administered agmatine on PS\u2010mediated behavioural and cognitive deficits of the offspring. Future studies are needed to elucidate the underlying mechanisms, which could allow for more targeted prenatal treatments.<\/jats:p>","DOI":"10.1002\/jdn.10277","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T06:35:40Z","timestamp":1685774140000},"page":"442-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring"],"prefix":"10.1002","volume":"83","author":[{"given":"Amin","family":"Hassanshahi","sequence":"first","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Physiology Bam University of Medical Sciences  Bam Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-3964","authenticated-orcid":false,"given":"Mahyar","family":"Janahmadi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moazamehosadat","family":"Razavinasab","sequence":"additional","affiliation":[{"name":"Kerman Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Ilaghi","sequence":"additional","affiliation":[{"name":"Kerman Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi A.","family":"Kohlmeier","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Hassanshahi","sequence":"additional","affiliation":[{"name":"Geriatric Care Research Center Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-5849","authenticated-orcid":false,"given":"Mohammad","family":"Shabani","sequence":"additional","affiliation":[{"name":"Kerman Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.11.015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90433-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90645-P"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1304.014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.10.011"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.12.018"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00532-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120972"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.06.002"},{"key":"e_1_2_12_11_1","unstructured":"Cherian S. 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