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Obesity may lead to cognitive disorders, depression and anxiety by affecting neuronal processes. <jats:italic>Spirulina platensis<\/jats:italic> (SP), a species of microalgae from the Chlorophyceae green algae class, has neuroprotective effects and may reduce body weight. In this study, we aimed to investigate the effects of SP on behavior alongside the role of leptin and Sirtuin\u20101 in fed with high\u2010fat diet (HFD) adolescent rats. Four\u2010week\u2010old Sprague Dawley male rats were divided into four groups: control, HFD, HFD\u2009+\u2009SP150 (150\u2009mg\/kg\/day SP, orally), HFD\u2009+\u2009SP450 (450\u2009mg\/kg\/day SP, orally). Rats except for the control group exposed to 60% HFD along 12\u2009weeks. Last 6\u2009weeks SP or vehicle administered. After the behavioral tests, leptin and Sirtuin\u20101 levels in prefrontal cortex and hippocampus regions were evaluated. SP150 significantly reduced body weight compared with HFD group. The time spent in the center of open field increased significantly in SP150\u2010treated rats compared with HFD. SP150 and SP450 significantly decreased immobility time in forced swim test compared with HFD. Leptin levels in HFD group were significantly lower in prefrontal cortex compared to control group. Leptin levels of the HFD\u2009+\u2009SP450 group were significantly higher than HFD group in the hippocampus. There was no significant difference between groups in Sirtuin\u20101 levels. In conclusion, SP supplementation in adolescence period might positively affect chronic high fat\u2010induced anxiety\u2010like and depressive\u2010like behavior by partially affecting brain leptin levels and without affecting Sirtuin\u20101 levels.<\/jats:p>","DOI":"10.1002\/jdn.10281","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:06:37Z","timestamp":1686787597000},"page":"505-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of <i>Spirulina platensis<\/i> on behavior in adolescent rats fed a high\u2010fat diet"],"prefix":"10.1002","volume":"83","author":[{"given":"Gizem","family":"Usluel","sequence":"first","affiliation":[{"name":"Department of Physiology Dokuz Eylul University Medical Faculty  Izmir Turkey"},{"name":"Health Sciences Institute Dokuz Eylul University  Izmir 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