{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:59:00Z","timestamp":1783717140623,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["4\u20105"],"award-info":[{"award-number":["4\u20105"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["3\u201010"],"award-info":[{"award-number":["3\u201010"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disease caused by <jats:italic>ATP1A3<\/jats:italic> mutations. Using voxel\u2010based morphometry (VBM) analysis, we compared an AHC patient cohort with controls. Additionally, with single\u2010case VBM analysis, we assessed the associations between clinical severity and brain volume in patients with AHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>To investigate structural brain changes in gray matter (GM) and white matter (WM) volumes between 9 patients with AHC and 20 age\u2010matched controls, VBM analysis was performed using three\u2010dimensional T1\u2010weighted magnetic resonance imaging. Single\u2010case VBM analysis was also performed on nine patients with AHC to investigate the associations between the respective volumes of GM\/WM differences and the motor level, cognitive level, and status epilepticus severity in patients with AHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, patients with AHC showed significant GM volume reductions in both hippocampi and diffuse cerebellum, and there were WM reductions in both cerebral hemispheres. In patients with AHC, cases with more motor dysfunction, the less GM\/WM volume of cerebellum was shown. Three of the six cases with cognitive dysfunction showed a clear GM volume reduction in the insulae. Five of the six cases with status epilepticus showed the GM volume reduction in hippocampi. One case had severe status epilepticus without motor dysfunction and showed no cerebellar atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With single\u2010case VBM analysis, we could show the association between region\u2010specific changes in brain volume and the severity of various clinical symptoms even in a small sample of subjects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10295","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:39:57Z","timestamp":1692682797000},"page":"665-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain structural changes in alternating hemiplegia of childhood using single\u2010case voxel\u2010based morphometry analysis"],"prefix":"10.1002","volume":"83","author":[{"given":"Elly","family":"Arizono","sequence":"first","affiliation":[{"name":"Department of Radiology, National Center Hospital National Center 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