{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:43:35Z","timestamp":1781905415638,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004350"],"award-info":[{"award-number":["82004350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Perinatal hypoxic\u2013ischemic encephalopathy (HIE) is a condition that can lead to long\u2010term cognitive, motor, and behavioral impairments in newborns. Although brain hypothermia therapy is currently the standard treatment for HIE, it does not provide complete neuroprotection. As a result, there is a need to explore additional therapies to enhance treatment outcomes. This study aims to investigate the potential role of Ginkgolide B (GB) in promoting neuroplasticity and facilitating spontaneous recovery after HIE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we employed a neonatal rat model of HIE to investigate the effects of GB on spontaneous recovery. GB treatment was initiated 24\u2009h after hypoxia and administered continuously for a duration of 14\u2009days. We evaluated several outcome measures after the treatment period, including spontaneous behavioral recovery and brain repair. Additionally, we quantified the levels of netrin\u20101 in both plasma and the peri\u2010ischemic zone after the occurrence of HIE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that GB treatment significantly facilitated spontaneous behavioral recovery in the HIE pups. Furthermore, cognitive function was restored, and brain tissue repair had a noticeable acceleration. We observed increased cell proliferation in the subventricular, stratum, and subgranular zones. Of particular interest, we observed elevated levels of netrin\u20101 in both plasma and the ischemic penumbra following GB treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that GB promotes neuroplasticity and enhances spontaneous recovery in newborns affected by HIE. The observed upregulation of netrin\u20101 may be crucial in mediating these effects. These results highlight the promising potential of GB as a post\u2010HIE therapy, particularly in enhancing spontaneous recovery and improving long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10301","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:05:27Z","timestamp":1695971127000},"page":"740-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ginkgolide B promotes spontaneous recovery and enhances endogenous netrin\u20101 after neonatal hypoxic\u2013ischemic brain damage"],"prefix":"10.1002","volume":"83","author":[{"given":"Aiming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Psychology, Shenzhen Traditional Chinese Medicine Hospital Fourth Clinical Medical College of Guangzhou University of Chinese Medicine  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengzhan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9006-1574","authenticated-orcid":false,"given":"Huiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Vasculocardiology The Affiliated Taizhou Second People's Hospital of Yangzhou University  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3834-03.2004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2022.2041778"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7254"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2018.07.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21393"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(02)00233-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-011-0373-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-019-0125-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060049"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0602-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260967.77422.97"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706930"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062095"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.056"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.032"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-58"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112243"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03726-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7220"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114464"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220302150723"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0504-z"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4137\/IMI.S25054"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.019"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.05.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.096"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.08.002"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00114-0"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.10301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T10:30:15Z","timestamp":1702981815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jdn.10301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jdn.10301"],"URL":"https:\/\/doi.org\/10.1002\/jdn.10301","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"2023-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}