{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:33:08Z","timestamp":1767137588478,"version":"build-2238731810"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["98001159"],"award-info":[{"award-number":["98001159"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autism spectrum disorder (ASD) is a widespread neurodevelopmental disorder with unknown etiology. Dysfunction of several brain areas including the prefrontal cortex (PFC), hippocampus, and cerebellum is involved in cognitive and behavioral deficits associated with ASD. Several studies have reported a reduction in the number of parvalbumin\u2010immunoreactive (PV\n                    <jats:sup>+<\/jats:sup>\n                    ) neurons in brain areas of ASD patients and animal models such as a shank mutant mouse model and rodents receiving fetal valproic acid (VPA) administration. Developing therapeutic interventions that restore PV interneurons can be the future therapeutic approach to ASD. The present study examined the possible effect of agmatine (AG), an endogenous NMDA antagonist, on the number of PV\n                    <jats:sup>+<\/jats:sup>\n                    neurons in a VPA animal model of autism. The therapeutic effects of AG in ameliorating ASD\u2010like behaviors were previously reported in VPA rats. AG was gavaged at dosages of 0.001, 0.01, and 0.1\u00a0mg\/kg from gestational day (GD) 6.5 to 18.5, and the number of PV interneurons was analyzed by immunohistochemistry in the 1\u2010month\u2010old rats. Prenatal VPA (GD 12.5) or AG led to a decrease of PV neurons in the PFC, Cornu ammonia (CA1), and molecular layers (MLs) of the cerebellum. However, exposure to AG restored the PV population induced by VPA. AG may modify underlying neuronal mechanisms resulting in the increased survival or restoration of the PV population.\n                  <\/jats:p>","DOI":"10.1002\/jdn.10314","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:34:06Z","timestamp":1706848446000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Agmatine ameliorates valproic acid\u2010induced depletion of parvalbumin\u2010positive neuron"],"prefix":"10.1002","volume":"84","author":[{"given":"Khadijeh Mirzaee","family":"Khoram\u2010Abadi","sequence":"first","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"},{"name":"Department of Anatomical Sciences, Afzalipour School of Medicine Kerman University of Medical Sciences  Kerman 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