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Unfortunately, the age at which individuals begin drinking alcohol has decreased in recent years, which has drawn attention to the effects of alcohol on neurological changes during preadolescence. In this study, we investigated the effects of adolescent intermittent ethanol (AIE) exposure on the cellular composition of the cerebellum in male rats, particularly when alcohol consumption begins early. The male rats received eight doses of intermittent intraperitoneal injection of 25% (v\/v) ethanol (3\u00a0g\/kg) or saline from postnatal days (PND) 25 to PND 38. In rats, 28\u201342\u2009days old corresponds to 10\u201318\u2009years old in humans. Two hours after the last injection, the cells, neurons, and non\u2010neuronal cells in the cerebellum were immunocytochemically labeled and the total numbers of related cells were calculated using the Isotropic Fractionator method. We found that AIE exposure does not change the cell numbers of the cerebellum in the short term, but it does activate astrocytes in the white matter of the cerebellum. These findings suggest that alcohol use during adolescence impairs the innate immune system and negatively affects brain plasticity.<\/jats:p>","DOI":"10.1002\/jdn.10317","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T07:00:01Z","timestamp":1707375601000},"page":"177-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adolescent intermittent ethanol use in male rats do not change cerebellar cell numbers but initiate astroglial reaction"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-3810","authenticated-orcid":false,"given":"Nurhan","family":"\u00c7on","sequence":"first","affiliation":[{"name":"Department of Medical Services and Techniques Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevcan","family":"Mercan","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"K\u00fc\u00e7\u00fck\u00f6ner","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00fcket","family":"\u00c7ali\u015fkan","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2014.07.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad059"},{"key":"e_1_2_8_4_1","unstructured":"Bancroft J. 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