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In addition, several studies reported atrophy, metabolic changes, and neuronal degeneration in the dorsal striatum. The literature lacks studies investigating potential neuronal damage in the ventral component of the striatopallidal complex (ventral striatum [VS] and ventral pallidum) in SE experimentations. To better understand the development of neuronal damage in the striatopallidal complex associated with SE, the detected neuronal degeneration in the compartments of the VS, namely, the nucleus accumbens (NAc) and the olfactory tubercle (OT), was analyzed. The experiments were performed on Wistar rats at age of 25\u2010day\u2010old pups and 3\u2010month\u2010old adult animals. Lithium\u2013pilocarpine model of SE was used. Lithium chloride (3\u00a0mmol\/kg, ip) was injected 24\u2009h before administering pilocarpine (40\u2009mg\/kg, ip). This presented study demonstrates the variability of post SE neuronal damage in 25\u2010day\u2010old pups in comparison with 3\u2010month\u2010old adult rats. The NAc exhibited small to moderate number of Fluoro\u2010Jade B (FJB)\u2010positive neurons detected 4 and 8\u00a0h post SE intervals. The number of degenerated neurons in the shell subdivision of the NAc significantly increased at survival interval of 12\u2009h after the SE. FJB\u2010positive neurons were evidently more prominent occupying the whole anteroposterior and mediolateral extent of the nucleus at longer survival intervals of 24 and 48\u2009h after the SE. This was also the case in the bordering vicinity between the shell and the core compartments but with clusters of degenerating cells. The severity of damage of the shell subdivision of the NAc reached its peak at an interval of 24\u2009h post SE. Isolated FJB\u2010positive neurons were detected in the ventral peripheral part of the core compartment. Degenerated neurons persisted in the shell subdivision of the NAc 1\u2009week after SE. However, the quantity of cell damage had significantly reduced in comparison with the aforementioned shorter intervals. The third layer of the OT exhibited more degenerated neurons than the second layer. The FJB\u2010positive cells in the young animals were higher than in the adult animals. The morphology of those cells was identical in the two age groups except in the OT.<\/jats:p>","DOI":"10.1002\/jdn.10331","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T23:59:00Z","timestamp":1713398340000},"page":"328-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Compartmental neuronal degeneration in the ventral striatum induced by status epilepticus in young rats' brain in comparison with adults"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-4407","authenticated-orcid":false,"given":"Azzat","family":"Al\u2010Redouan","sequence":"first","affiliation":[{"name":"Department of Anatomy, Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Salaj","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Kubova","sequence":"additional","affiliation":[{"name":"Department of developmental Epileptology, Institute of Physiology The Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rastislav","family":"Druga","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Second Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Department of developmental Epileptology, Institute of Physiology The Czech Academy of Sciences  Prague Czech Republic"},{"name":"Institute of Anatomy, First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.12.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03725.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70626-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902990206"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.01.028"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02506.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000297514.47695.48"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903380209"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00052.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14919"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1991.tb05533.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00600.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2473-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(99)00119-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09258.x"},{"key":"e_1_2_11_19_1","first-page":"1","article-title":"Rhinencephalic structures and their anatomical organization","volume":"117","author":"Druga R.","year":"1987","journal-title":"Acta Universitatis Carolinae. 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