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In this study, we investigated the early life behavioral consequences of a single injection of lipopolysaccharide (LPS) at postnatal day 10 (PD10) in mice. To assess deficits in communication, we performed the isolation\u2010induced ultrasonic vocalizations (USVs) test at PD12. To determine if early life immune stimulus could alter seizure susceptibility, latency to flurothyl\u2010induced generalized seizures was measured at 4 hours\u00a0(hrs), 2\u00a0days, or 5\u00a0days after LPS injections. LPS had a sex\u2010dependent effect on USV number. LPS\u2010treated male mice presented significantly fewer USVs than LPS\u2010treated female mice. However, the number of calls did not significantly differ between control and LPS for either sex. In male mice, we found that downward, short, and composite calls were significantly more prevalent in the LPS treatment group, while upward, chevron, and complex calls were less prevalent than in controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). Female mice that received LPS presented a significantly higher proportion of short, frequency steps, two\u2010syllable, and composite calls in their repertoire when compared with female control mice (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). Seizure latency was not altered by early\u2010life inflammation at any of the time points measured. Our findings suggest that early\u2010life immune stimulation at PD10 disrupts vocal development but does not alter the susceptibility to flurothyl\u2010induced seizures during the neonatal period. Additionally, the effect of inflammation in the disruption of vocalization is sex\u2010dependent.<\/jats:p>","DOI":"10.1002\/jdn.10333","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T09:26:49Z","timestamp":1715074009000},"page":"381-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal immune stimulation results in sex\u2010specific changes in ultrasonic vocalizations but does not affect seizure susceptibility in neonatal mice"],"prefix":"10.1002","volume":"84","author":[{"given":"Danielle","family":"Santana\u2010Coelho","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University  Waco Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J.","family":"Pranske","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Baylor University  Waco Texas 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