{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:31:40Z","timestamp":1782930700541,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T00:00:00Z","timestamp":1716595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT;BT\/PR23123\/MED\/122\/67\/2017"],"award-info":[{"award-number":["DBT;BT\/PR23123\/MED\/122\/67\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DSTINSPIRE;IF180771"],"award-info":[{"award-number":["DSTINSPIRE;IF180771"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Modulation of in vivo adult neurogenesis (AN) is an evolving concept in managing neurodegenerative diseases. CDRI\u201008, a bacoside\u2010enriched fraction of <jats:styled-content style=\"fixed-case\"><jats:italic>Bacopa\u2009monnieri<\/jats:italic><\/jats:styled-content>, has been demonstrated for its neuroprotective actions, but its effect on AN remains unexplored. This article describes the status of AN by monitoring neuronal stem cells (NSCs) proliferation, differentiation\/maturation markers and BDNF\u2013TrkB levels (NSCs signalling players) vs. the level of neurodegeneration and their modulations by CDRI\u201008 in the hippocampal dentate gyrus (DG) of male rats with moderate grade hepatic encephalopathy (MoHE). For NSC proliferation, 10\u00a0mg\/kg b.w. 5\u2010bromo\u20102\u2032\u2010deoxyuridine (BrdU) was administered i.p. during the last 3\u00a0days, and for the NSC differentiation study, it was given during the first 3\u00a0days to the control, the MoHE (developed by 100\u2009mg\/kg b.w. of thioacetamide i.p. up to 10\u00a0days) and to the MoHE male rats co\u2010treated with 350\u2009mg\/kg b.w. CDRI\u201008. Compared with the control rats, the hippocampus DG region of MoHE rats showed significant decreases in the number of Nestin<jats:sup>+<\/jats:sup>\/BrdU<jats:sup>+<\/jats:sup> and SOX2<jats:sup>+<\/jats:sup>\/BrdU<jats:sup>+<\/jats:sup> (proliferating) and DCX<jats:sup>+<\/jats:sup>\/BrdU<jats:sup>+<\/jats:sup> and NeuN<jats:sup>+<\/jats:sup>\/BrdU<jats:sup>+<\/jats:sup> (differentiating) NSCs. This was consistent with a similar decline in BDNF<jats:sup>+<\/jats:sup>\/TrkB<jats:sup>+<\/jats:sup> NSCs. However, all these NSC marker positive cells were observed to be recovered to their control levels, with a concordant restoration of total cell numbers in the DG of the CDRI\u201008\u2010treated MoHE rats. The findings suggest that the restoration of hippocampal AN by CDRI\u201008 is consistent with the recovery of BDNF\u2013TrkB\u2010expressing NSCs in the MoHE rat model of neurodegeneration.<\/jats:p>","DOI":"10.1002\/jdn.10350","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T12:28:56Z","timestamp":1716640136000},"page":"510-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Restoration of hippocampal adult neurogenesis by CDRI\u201008 (<scp><i>Bacopa\u2009monnieri<\/i><\/scp> extract) relates with the recovery of BDNF\u2013TrkB levels in male rats with moderate grade hepatic encephalopathy"],"prefix":"10.1002","volume":"84","author":[{"given":"Debasmit","family":"Mallick","sequence":"first","affiliation":[{"name":"Biochemistry Section, Department of Zoology, Institute of Science Banaras Hindu University  Varanasi 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