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Melatonin administration following brain insults has been considered a promising therapeutic strategy due to its antioxidant and anti\u2010inflammatory effects. Not surprisingly, it has been extensively studied for preventing disturbances following brain injury. This study evaluated the effects of melatonin on developmental disturbances, memory disruption, and hippocampal cell loss induced by neonatal anoxia in rats. Neonatal Wistar rats were subjected to anoxia and subsequently treated with melatonin. Later, maturation of physical characteristics, ontogeny of reflexes, learning and memory in the Morris water maze (MWM), and estimates of the number of hippocampal neurons, were evaluated. Melatonin treatment attenuated (1) female anoxia\u2010induced delay in superior incisor eruption, (2) female anoxia\u2010induced vibrissae placement reflexes, and (3) male and female anoxia\u2010induced hippocampal neuronal loss. Melatonin also promoted an increase (5) in swimming speeds in the MWM. In addition, PCA analysis showed positive associations between the acoustic startle, auditory canal open, and free fall righting parameters and negative associations between the male vehicle anoxia group and the male melatonin anoxia group. Therefore, melatonin treatment attenuates both anoxia\u2010induced developmental deficits and hippocampal neuronal loss.<\/jats:p>","DOI":"10.1002\/jdn.10351","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:46:16Z","timestamp":1718081176000},"page":"520-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin attenuates developmental deficits and prevents hippocampal injuries in male and female rats subjected to neonatal anoxia"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-6906","authenticated-orcid":false,"given":"Bruna Petrucelli","family":"Arruda","sequence":"first","affiliation":[{"name":"Neurosciences Laboratory, Department of Anatomy, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia 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