{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:55:35Z","timestamp":1787766935136,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to ascertain the serum levels of selectins (E, L, P) and platelet\u2010endothelial adhesion molecule\u20101 (PECAM\u20101) in preschool children with autism spectrum disorder (ASD) and to establish a comparison with the levels observed in healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 34 children aged 2\u20137\u2009years diagnosed with ASD (ASD group) and 34 randomly selected healthy children matched for age and sex to the ASD group. The children were free of any genetic or physical disease, clinically active infection, or medication use. The sociodemographic data form was completed by all parents. The Childhood Autism Rating Scale (CARS) and the Autism Behavior Checklist (ABC) were administered to the patient group, and the Aberrant Behavior Checklist (AbBC) was completed by the families of all children. Serum selectin (E, L, P) and PECAM\u20101 levels were measured using enzyme\u2010linked immunosorbent assay (ELISA) kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that the levels of both L\u2010selectin (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and PECAM\u20101 (<jats:italic>p<\/jats:italic>\u2009=\u20090.019) were significantly lower in the ASD group than in the control group. No significant difference was observed between the groups concerning E\u2010selectin and P\u2010selectin levels (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). It was observed that P\u2010selectin variables were statistically significant in predicting the presence of ASD (<jats:italic>p<\/jats:italic>\u2009=\u20090.019). A remarkable inverse correlation was found between the AbBC irritability subscale score and L\u2010selectin (r\u2009=\u2009\u22120.296, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and PECAM\u20101 (r\u2009=\u2009\u22120.276, <jats:italic>p<\/jats:italic>\u2009=\u20090. 023); the AbBC Lethargy\u2010Social Withdrawal subscale score and E\u2010Selectin (r\u2009=\u2009\u22120.239, <jats:italic>p<\/jats:italic>\u2009=\u20090.049), L\u2010Selectin (r\u2009=\u2009\u22120.297, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and PECAM\u20101 (r\u2009=\u2009\u22120.264, <jats:italic>p<\/jats:italic>\u2009=\u20090.029); L\u2010Selectin levels and the AbBC <jats:bold>stereotypic behavior<\/jats:bold> subscale (r\u2009=\u2009\u22120.248, <jats:italic>p<\/jats:italic>\u2009=\u20090.042). No statistically significant relationship was observed between selectins (E, L, P) and PECAM\u20101 levels and CARS scale, ABC subscale or total scores and age variables (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These study results suggest that L\u2010selectin, P\u2010selectin and PECAM\u20101 may play a role in the pathophysiology of ASD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jdn.10377","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T10:46:53Z","timestamp":1726742813000},"page":"867-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Decreased levels of L\u2010selectin and platelet\u2010endothelial cell adhesion molecule\u20101 in children with autism spectrum disorder"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-5853","authenticated-orcid":false,"given":"Semiha C\u00f6merto\u011flu","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyzullah Necati","family":"Arslan","sequence":"additional","affiliation":[{"name":"Developmental\u2010Behavioral Pediatrics Division, Department of Pediatrics Kahramanmara\u015f Necip Fazil City Hospital  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-8216","authenticated-orcid":false,"given":"Hatice","family":"Altun","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilan","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9921-6916","authenticated-orcid":false,"given":"Elif Milhan","family":"Islah","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-7549","authenticated-orcid":false,"given":"Muhammed","family":"Seyithano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Do\u011faner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine Kahramanmara\u015f S\u00fct\u00e7\u00fc \u0130mam University  Kahramanmara\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"5","key":"e_1_2_13_2_1","first-page":"485","article-title":"The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects","volume":"89","author":"Aman M. 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