{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:14:30Z","timestamp":1788786870066,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study investigated metaplasticity\u2010related mRNA expressions in valproic acid (VPA)\u2010rats, focusing on the PI3K\/AKT pathway. Wistar dams were treated with a single intraperitoneal injection of 600\u2009mg\/kg VPA or saline on embryonic day E12.5 or an equal volume of saline solution. Three behavioral tests were conducted on these males' offspring: grid\u2010walking test, negative geotaxis test, and three\u2010chamber social interaction test. Metaplasticity was induced in 60\u2010day\u2010old male progeny by giving high\u2010frequency stimulation for 5\u00a0minutes following low\u2010frequency stimulation to the perforant pathway. For the baseline stimulation protocol (<jats:italic>n<\/jats:italic>\u00a0=\u20096), stimulation was delivered to the dentate gyrus at the previously determined stimulation intensity (0.33\u2009Hz 0.175\u2009msec 30\u2009s) for 75\u2009min. The percent change of slope of field excitatory postsynaptic potential (fEPSP) and amplitude of population spike were calculated 55\u201360\u2009min after induction protocol. The mRNA levels of PI3K, PTEN, AKT, GSK\u20103\u03b2, and MAPT were measured in the hippocampus by using quantitative rt\u2010PCR. We found that offspring of VPA\u2010treated rats showed significantly impaired sensorimotor coordination, decreased sociability, impaired preference for social novelty, and reduced input\u2013output curve of fEPSP slope, compared to control animals. Despite a similar metaplastic response, mRNA levels of genes of interest were similar but considerably down\u2010regulated after induction in offspring of VPA\u2010treated dams. Our study provides evidence that the induced expression of autism\u2010related genes has evolved to enable an adaptation mechanism during metaplastic control of long\u2010term potentiation.<\/jats:p>","DOI":"10.1002\/jdn.10398","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:34:11Z","timestamp":1733099651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic machinery which accompanies metaplasticity operates differentially in experimental model of autism"],"prefix":"10.1002","volume":"85","author":[{"given":"Esra Tufan","family":"Benli","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physiology, Institute of Health Sciences COHE 100\/2000 Doctorate Program, Human Brain and Neuroscience Sub\u2010Field Recites University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-6423","authenticated-orcid":false,"given":"Ercan","family":"Babur","sequence":"additional","affiliation":[{"name":"Physiology Department of Medical School University of Erciyes  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Dursun","sequence":"additional","affiliation":[{"name":"Physiology Department of Medical School University of Erciyes  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Saray","sequence":"additional","affiliation":[{"name":"Physiology Department of Medical School University of Erciyes  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Barut\u00e7u","sequence":"additional","affiliation":[{"name":"Physiology Department of Medical School University of Erciyes  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"S\u00fcer","sequence":"additional","affiliation":[{"name":"Physiology Department of Medical School University of Erciyes  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.08.015"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"S160","article-title":"Early behavioral abnormalities and perinatal alterations of Pten\/Akt pathways in valproic acid autism model mice","volume":"130","author":"Ahn S.","year":"2016","journal-title":"Journal of Pharmacological Sciences"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000536045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.03.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375489"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23277"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(99)00980-5"},{"issue":"3","key":"e_1_2_11_9_1","first-page":"305","article-title":"The long\u2010term suppressive effect of prior activation of synaptic inputs by low\u2010frequency stimulation on induction of long\u2010term potentiation in CA1 neurons of guinea pig hippocampal slices. [research support, non\u2010U.S. Gov't]","volume":"111","author":"Fujii S.","year":"1996","journal-title":"Experimental Brain Research"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063209"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.01.009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835ea0b2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00359"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-009-9023-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.02.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00222895.2015.1024824"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/Fnbeh.2018.00182"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27400"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.133"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20383"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/Rstb.2013.0144"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.Tox.2020.152500"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.05.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/Fnmol.2014.00027"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00228-9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2003.10.013"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00023"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026077"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac221"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/Jneurosci.3614-09.2010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.030"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00071.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.04.017"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.02.014"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3625-15.2016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.029"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160202121111"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_404"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704391104"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300518"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2022.113739"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.01.011"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.038"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153298"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-019-01323-x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115069"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00195-9"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.08.010"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089071"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009886"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.10398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T14:45:53Z","timestamp":1741790753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jdn.10398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jdn.10398"],"URL":"https:\/\/doi.org\/10.1002\/jdn.10398","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10398"}}