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Methamphetamine can readily cross anatomical barriers like the blood\u2010placenta barrier and cause detrimental impacts on the growing fetus. The current research evaluated the effects of prenatal methamphetamine exposure on helping behaviour and neuroinflammatory cascade in the amygdala of male offspring. On the tenth day of pregnancy, female rats received either saline or methamphetamine (5\u2009mg\/kg) until delivery. Once the offspring reached 21\u2009days of age, the male ones were sep arated from their mothers and housed with normal male rats. An empathy\u2010like behaviour test, which measured helping behaviour towards the cage mate, was conducted. The expression levels of miR\u2010223\u20103p, NLRP3, Caspase 1, and gasdermin D (GSDMD) were evaluated in the amygdala of male offspring. Moreover, interleukin\u20101\u03b2 (IL\u20101\u03b2) protein level was measured. Findings of this study revealed that male offspring exposed to methamphetamine during pregnancy had impaired helping behaviour. At the molecular level, prenatal methamphetamine exposure decreased miR\u2010223\u20103p and increased inflammasome signaling by raising the levels of NLRP3, caspase\u20101, and GSDMD along with IL\u20101\u03b2 levels. These findings indicate that prenatal methamphetamine exposure impairs emotional behaviour and activates inflammasome pathway in the amygdala.<\/jats:p>","DOI":"10.1002\/jdn.10410","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:59:33Z","timestamp":1735210773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Methamphetamine Exposure Impairs Helping Behaviour in Male Offspring: The Possible Role of miR\u2010223 and NLRP3 Inflammasomes in the Amygdala"],"prefix":"10.1002","volume":"85","author":[{"given":"Fariba","family":"Khodagholi","sequence":"first","affiliation":[{"name":"Neuroscience Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-8750","authenticated-orcid":false,"given":"Mitra\u00a0Ansari","family":"Dezfouli","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-8735","authenticated-orcid":false,"given":"Neda","family":"Yazdanfar","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed\u00a0Khalil","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Faculty of Medicine Semnan University of Medical Sciences  Semnan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman\u00a0Zeinaddin","family":"Meymand","sequence":"additional","affiliation":[{"name":"Sina Truma and Surgery Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pegah","family":"Javadpour","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed\u00a0Hamidreza","family":"Mirbehbahani","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayereh","family":"Zare","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Cognitive Neurosciences, Faculty of Medicine, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2023.112493"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.02.006"},{"key":"e_1_2_10_4_1","unstructured":"Institute of Laboratory Animal Resources (US).1986. 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