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Pregnant Wistar Albino rats were administered either 400\u2009mg\/kg VPA or saline i.p. on E12.5. Empathy\u2010like behaviour was assessed at P30 and P60 in both female and male offspring, who were also tested for olfactory discrimination, sociability, locomotor activity, and pre\u2010pulse inhibition. Prenatal exposure to VPA significantly impaired empathy\u2010like behaviour, as measured by the duration of time the subject spent with its sibling and the frequency of attempts to open the restrainer door. When P30 and P60 results were compared within groups, a developmental arrest in empathy\u2010like behaviour was observed in the VPA group, whereas the control group showed improvement in their scores. Prenatal exposure to VPA also resulted in significantly decreased sociability and pre\u2010pulse inhibition rates. In this study, an adapted version for measuring empathy\u2010like behaviour has been proposed. This version involved a restrained sibling and no prior training, allowing the measurement to be independent of learning, memory, and stranger anxiety. The results show that VPA has negative effects on social development and is a valid tool for modelling ASD in both females and males.<\/jats:p>","DOI":"10.1002\/jdn.70008","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:35:55Z","timestamp":1741707355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of Empathy\u2010Like Behaviour in Valproic Acid\u2013Induced Rat Model of Autism"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5723-0769","authenticated-orcid":false,"given":"S\u00fceda","family":"Tun\u00e7ak","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Bursa Uluda\u011f University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"G\u00f6ren","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Bursa Uluda\u011f University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"Uzbay","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Application and Research Center TC \u00dcsk\u00fcdar University  \u0130stanbul Turkey"},{"name":"Department of Internal Medicine, Faculty of Medicine TC \u00dcsk\u00fcdar University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Application and Research Center TC \u00dcsk\u00fcdar University  \u0130stanbul Turkey"},{"name":"Department of Molecular Biology and Genetics (Engl.), Faculty of Engineering and Natural Sciences TC \u00dcsk\u00fcdar University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2993","article-title":"Alteration in Social Interaction and Tactile Discrimination of Juvenile Autistic\u2010Like Rats Following Tactile Stimulation and Whisker Deprivation","volume":"13","author":"Ahmadi B. 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