{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:54:23Z","timestamp":1773035663147,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Traumatic brain injury (TBI) is a major public health problem and an essential cause of morbidity and mortality during childhood. The aim of this study was to evaluate the apoptotic effects of MK\u2010801, a noncompetitive NMDA receptor antagonist, on hippocampal damage in 10\u2010day\u2010old rat pups exposed to contusion injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two Wistar Albino rats were randomly assigned to three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914 per group): control, trauma and MK\u2010801 treatment. In the treatment group, MK\u2010801 was administered intraperitoneally at a dose of 1\u2009mg\/kg immediately after induction of TBI. Apoptotic damage in the hippocampal dentate gyrus (DG) and CA1 regions was assessed using immunoreactivity for BAX, cytochrome c and caspase\u20103.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The control group showed low levels of BAX and cytochrome c immunoreactivity in the hippocampus, whereas the TBI group exhibited markedly increased reactions. Cytochrome c immunoreactivity appeared in a granular pattern within neurons of the DG region. In the MK\u2010801 treatment group, both BAX and cytochrome c immunoreactivities were reduced compared to the TBI group. While only weak caspase\u20103 immunoreactivity was observed in the control group, intense immunoreactivity was detected in both the DG and CA1 regions of the hippocampus in the TBI group. In contrast, caspase\u20103 immunoreactivity was notably reduced in the MK\u2010801 group compared to the TBI group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that treatment with MK\u2010801 significantly reduces apoptosis in the hippocampus by downregulating key pro\u2010apoptotic markers, including BAX, cytochrome c and caspase\u20103. These findings suggest that MK\u2010801 exerts a neuroprotective effect by interfering with the intrinsic apoptotic pathway following TBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jdn.70043","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T08:11:03Z","timestamp":1754640663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of MK\u2010801 on Apoptosis in Immature Rats With Traumatic Brain Injury"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9512-6997","authenticated-orcid":false,"given":"Ay\u015fe","family":"\u00c7i\u011fel","sequence":"first","affiliation":[{"name":"Department of Physiology Izmir Democracy University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-9091","authenticated-orcid":false,"given":"Oya","family":"Say\u0131n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Dokuz Eyl\u00fcl University Vocational School of Health Services  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-1404","authenticated-orcid":false,"given":"Seren\u00a0G\u00fcl\u015fen","family":"G\u00fcrgen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Manisa Celal Bayar University Vocational School of Health Services  Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-1693","authenticated-orcid":false,"given":"Talha\u00a0Ba\u015far","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Physiology Dokuz Eyl\u00fcl University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-9804","authenticated-orcid":false,"given":"Ata\u00e7","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Physiology Dokuz Eyl\u00fcl University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065897"},{"key":"e_1_2_13_3_1","volume-title":"Impact of Open Channel Blockers on the Surface Dynamics and Organization of NMDA Receptors","author":"Fernandes A.","year":"2020"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002730\u2010z"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2023.105587"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb11841.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010009\u20100608\u2010x"},{"key":"e_1_2_13_8_1","volume-title":"StatPearls. 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