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Mutation\u2010induced loss of its functions in mammals leads to severe disorders associated with impaired motor coordination, tremors and ataxia. Little is known about Reelin's role in functional recovery after central nervous system injury. We determined the effect of knock\u2010down of Reelin and its downstream signal\u2010transducing molecule Disabled\u20101 (Dab\u20101) on functional recovery after spinal cord injury in larval zebrafish. Larvae deficient in Reelin and Dab\u20101 were generated by application of two non\u2010overlapping antisense morpholinos for each molecule. Individual knock\u2010down of Reelin and Dab\u20101 expression impaired locomotor recovery after injury, inhibited remyelination of regrown axons and reduced numbers of motor neurons caudal to the lesion site. These results indicate that the Reelin\/Dab\u20101 signalling pathway is involved in axon regeneration after injury of a paradigmatic vertebrate in the central nervous system.<\/jats:p>","DOI":"10.1002\/jdn.70045","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:30:41Z","timestamp":1755063041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reelin\/Disabled\u20101 Signalling Contributes to Functional Recovery on Zebrafish After Spinal Cord Injury"],"prefix":"10.1002","volume":"85","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[{"name":"Center for Neuroscience Shantou University Medical College  Shantou Guangdong China"},{"name":"School of Optometry The Hong Kong Polytechnic University  Kowloon Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-2428","authenticated-orcid":false,"given":"Sudhanshu","family":"Sahu","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Shantou University Medical College  Shantou Guangdong China"},{"name":"Institute of Life Sciences  Bhubaneswar Odisha India"},{"name":"Department of Pharmacology DRIEMS Institute of Health Sciences and Hospital  Cuttack Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207178200"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X04000092"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4566-05.2006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000703)422:3<448::AID-CNE10>3.0.CO;2-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890500407520"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2008.11760720"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.0966"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.167"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10292"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80860-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02996215"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90338-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.99"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-018-0122-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-05797.2002"},{"key":"e_1_2_10_17_1","first-page":"5969","article-title":"3D Imaging for Quantitative Assessment of Toxicity on Vascular Development in Zebrafish","volume":"2011","author":"Hans C.","year":"2011","journal-title":"Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690406"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199710)210:2<157::AID-AJA8>3.0.CO;2-F"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2012.01327.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.472734"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020636.27222.2d"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-011-1186-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4036-10.2010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2018.05.013"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05978.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15311-x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0001-8"},{"key":"e_1_2_10_32_1","article-title":"Using Morpholinos to Control Gene Expression","author":"Moulton J. 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