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Studies in rodents have demonstrated that VPA exposure during the first trimester\u2010equivalent period of gestation results in a lifelong autistic\u2010like phenotype. A growing body of evidence suggests that VPA exposure may be a risk factor for ASD beyond the first trimester of pregnancy. Here, we investigated in adolescent Swiss mice the neurobehavioural effects of exposure to VPA during the brain growth spurt, a period that encompasses the third trimester of human gestation. Offspring received ip injections of VPA (200\u2009mg\/kg) or saline solution (NaCl 0.9%) on alternate days, from Postnatal Day 2 (PN2) to PN8. Animals were behaviourally tested either as juveniles (PN12: sociability [aggregation]) or adolescents (PN30: anxiety\u2010like behaviour [elevated plus maze], locomotor activity [open field], repetitive behaviour [marble burying] and sociability [reciprocal social interaction and three\u2010chamber test]). At PN33, serotonin serum levels and frontal cortical norepinephrine, dopamine and DOPAC were evaluated by HPLC. No differences were observed at PN12. Adolescent VPA mice showed increased anxiety\u2010like behaviour, hyperactivity and reduced repetitive behaviour. Lower sociability was identified in the reciprocal social interaction. However, in the three\u2010chamber test, social behaviour was higher in the VPA group. It also showed higher serotonin, but no other neurotransmitter level effects were observed. The results support the idea that the period of brain growth spurt may be relevant for the manifestation of neurobehavioural deficits associated with ASD induced by VPA.<\/jats:p>","DOI":"10.1002\/jdn.70056","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T12:09:29Z","timestamp":1759406969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Valproic Acid Exposure During the Brain Growth Spurt Leads to Autistic\u2010Like Behaviours in Mice"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-4771","authenticated-orcid":false,"given":"Bruna","family":"Lotufo\u2010Denucci","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neurofisiologia, Departamento de Ci\u00eancias Fisiol\u00f3gicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biom\u00e9dico Universidade do Estado do Rio de Janeiro  Rio de Janeiro Rio de Janeiro 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