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Placental alterations, such as epigenetic DNA methylation and structural abnormalities, have been associated with ASD. Circular RNA (circRNA), covalently closed and highly stable molecules, play an epigenetic role by sequestering microRNA (miRNA) and modulating messenger RNA (mRNA) translation, forming posttranscriptional networks essential for gene expression. However, there is a lack of evidence in the literature regarding the involvement of circRNA, the placenta and ASD. To address this gap, the study aimed to map the interactions among circRNA, miRNA and mRNA, investigating their relevance to ASD and placental development using bioinformatics tools, such as\n                    <jats:italic>circATLAS<\/jats:italic>\n                    and\n                    <jats:italic>miRTargetLink<\/jats:italic>\n                    2.0. The analysis identified 71 circRNA linked to ASD and 30 highly expressed in the placenta, which regulate pathways such as \u2018immune response,\u2019 \u2018gene transcription,\u2019 and \u2018replication,\u2019 and others previously associated with ASD, such as \u2018Notch and AKT signalling pathway\u2019. Searches in the\n                    <jats:italic>SFARI<\/jats:italic>\n                    database revealed 11 relevant genes in the ASD group, nine in the placenta group and five shared genes (\n                    <jats:italic>SRSF11<\/jats:italic>\n                    ,\n                    <jats:italic>PSMD11<\/jats:italic>\n                    ,\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    ,\n                    <jats:italic>CREBBP<\/jats:italic>\n                    and\n                    <jats:italic>TBL1X<\/jats:italic>\n                    ). Further analysis identified the interaction of the circRNA hsa\u2010MAN1A2_0008 with miRNA associated with these genes. These findings suggest that highly expressed circRNA in the placenta regulate critical pathways for placental development and ASD aetiology, underscoring their role in linking placental alterations to ASD.\n                  <\/jats:p>","DOI":"10.1002\/jdn.70064","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T02:26:26Z","timestamp":1762914386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental Alterations in Autism Spectrum Disorder: An In Silico Approach to circRNA\u2013miRNA\u2013mRNA Networks"],"prefix":"10.1002","volume":"85","author":[{"given":"Brayan","family":"Braz\u2010Barbosa","sequence":"first","affiliation":[{"name":"Translational Research Group in Autism Spectrum Disorder\u2013GETTEA Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Biochemistry Universidade Federal do Rio Grande do Sul (UFRGS  Porto Alegre 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Initiative"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-452X","authenticated-orcid":false,"given":"J\u00falio","family":"Santos\u2010Terra","sequence":"additional","affiliation":[{"name":"Translational Research Group in Autism Spectrum Disorder\u2013GETTEA Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Biochemistry Universidade Federal do Rio Grande do Sul (UFRGS  Porto Alegre Brazil"},{"name":"National Institute of Science and Technology in Neuroimmunomodulation\u2013INCT\u2010NIM  Brazil"},{"name":"Autism Wellbeing and Research Development (AWARD)\u2013BR\u2010UK\u2010CA 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