{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:27:36Z","timestamp":1786422456100,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008323","name":"Zanjan University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.ZUMS.REC.1400.248"],"award-info":[{"award-number":["IR.ZUMS.REC.1400.248"]}],"id":[{"id":"10.13039\/501100008323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Little is known about how the effects of pregestational stress on seizure susceptibility in male and female offspring might be attenuated. The current study was undertaken to determine whether\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">Dracocephalum moldavica<\/jats:styled-content>\n                        (DM)\n                      <\/jats:italic>\n                      administration during gametogenesis could affect stress\u2010precipitated pentylenetetrazol (PTZ)\u2010induced seizure in the offspring of rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male and female Wistar rats were subjected to restraint stress and administered 100\u2009mg\/kg of DM extract orally for 50\u2009days (males) or 15\u2009days (females). The rats were then mated to generate eight coupling combinations, comprising four groups without DM extract and four groups with extract: McFc, McFs, MsFc, MsFs, McFc\u2009+\u2009EX, McFs\u2009+\u2009EX, MsFc\u2009+\u2009EX and MsFs\u2009+\u2009EX (M: male; F: female; C: control; S: stress; EX: extract). Pregnant dams were left undisturbed throughout gestation. Following parturition, each dam and her litter were housed in a separate cage under standard laboratory conditions until weaning. Offspring body weight was recorded at multiple time points. On the postnatal day (PND) 26, two pups per dam, one male and one female, were administered pentylenetetrazol (PTZ) intraperitoneally and evaluated for PTZ\u2010induced seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The DM extract significantly enhanced weight gain in offspring across all experimental groups compared with control pups. In addition, DM extract treatment reduced both the frequency and duration of tonic\u2013clonic seizures. Notably, the latency to the first epileptic manifestation was significantly prolonged in the MsFc+EX group compared with its corresponding control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The results indicated that\n                      <jats:italic>DM<\/jats:italic>\n                      extract attenuates pregestational stress precipitating epileptic behaviours probably by suppressing oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jdn.70142","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:14:57Z","timestamp":1780143297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Pregestational Stress and Concomitant Administration of\n                    <scp>\n                      <i>Dracocephalum moldavica<\/i>\n                    <\/scp>\n                    Extract on Seizure Behaviours in Next Generation Developing Rats"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-120X","authenticated-orcid":false,"given":"Hajar","family":"Ramezanikhah","sequence":"first","affiliation":[{"name":"Department of Persian Medicine, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Ghassemifard","sequence":"additional","affiliation":[{"name":"Department of Persian Medicine, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-4751","authenticated-orcid":false,"given":"Ehsan","family":"Saboory","sequence":"additional","affiliation":[{"name":"Department of Addiction Studies, School of Medicine Zanjan University of Medical Sciences  Zanjan Iran"},{"name":"Zanjan Metabolic Diseases Research Center, Health and Metabolic Diseases Research Institute Zanjan University of Medical Sciences  Zanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Persian Medicine, School of Medicine Zanjan University of Medical Sciences  Zanjan 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