{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:25:32Z","timestamp":1787192732478,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sodium channelopathies represent a leading monogenic cause of epilepsy, epileptic encephalopathy and autism spectrum disorder. Pathogenic variants in voltage\u2010gated sodium channels can lead to either gain\u2010of\u2010function or loss\u2010of\u2010function, resulting in highly diverse clinical phenotypes associated with the same gene. In this case report, we aimed to discuss a patient who presented with afebrile seizures at 6\u2009months of age and was diagnosed with \u2018self\u2010limited infantile epilepsy (SeLIE)\u2019 following the identification of a gain\u2010of\u2010function pathogenic variant in the\n                    <jats:italic>SCN8A<\/jats:italic>\n                    gene, in light of current guidelines and consensus recommendations. Furthermore, considering recent advancements, we aimed to emphasize that bioinformatic software tools for assessing the functional impact of pathogenic variants in ion channels can serve as a crucial guide for clinicians in treatment selection.\n                  <\/jats:p>","DOI":"10.1002\/jdn.70154","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:54:42Z","timestamp":1782449682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Bright Side of the Spectrum: Self\u2010Limited Infantile Epilepsy\u2010Related\n                    <i>SCN8A<\/i>\n                    Gof Variant"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-5997","authenticated-orcid":false,"given":"Fadime","family":"Keskin","sequence":"first","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics Tepecik Training and Research Hospital, 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-9995","authenticated-orcid":false,"given":"Gamze","family":"Sar\u0131kaya Uzan","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Pediatrics Tepecik Training and Research Hospital, University of Health Sciences  Izmir Turkey"},{"name":"Izmir Faculty of Medicine, Division of Child Neurology, Department of Pediatrics University of Health Sciences  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17992"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18569"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay6848"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40801"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14705"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab321"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010283"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2025.12.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.70063"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab162"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17239"}],"container-title":["International 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