{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:02:21Z","timestamp":1790143341162,"version":"4.0.1"},"reference-count":82,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Stress\u2010related experiences during early developmental periods may influence behavioural outcomes and hippocampal function. Social isolation is widely used as an experimental stress model, while physical exercise is considered a potential behavioural modulator. This study investigated the effects of treadmill exercise on behavioural performance and hippocampal synaptic plasticity following repeated partial daily social isolation in male rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Wistar rats (postnatal day 28) were assigned to control or repeated partial daily social isolation conditions (6\u2009h\/day for 6 weeks). Treadmill exercise was applied once daily for 4 weeks, starting after 2 weeks of isolation. Food and water intake and body weight were recorded weekly. Spatial learning and memory were assessed using the Morris Water Maze test, and hippocampal synaptic plasticity was evaluated via long\u2010term potentiation (LTP) recordings from the dentate gyrus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Social isolation and treadmill exercise significantly increased food and water consumption without affecting body weight. Social isolation did not significantly affect spatial learning, memory performance or dentate gyrus LTP. No significant differences were observed in Morris Water Maze performance or LTP measures among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings indicate that this moderate, intermittent isolation paradigm did not produce detectable alterations in hippocampal\u2010dependent spatial memory performance or dentate gyrus synaptic plasticity under the present experimental conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jdn.70177","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:36:00Z","timestamp":1789432560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Repeated Partial Daily Social Isolation and Treadmill Exercise on Spatial Memory and Hippocampal Long\u2010Term Potentiation in Male Rats"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-2334","authenticated-orcid":false,"given":"Neriman","family":"Ezgin","sequence":"first","affiliation":[{"name":"Institute of Natural and Applied Sciences, Department of Biotechnology Cukurova University  Adana Turkey"},{"name":"Institute of Medical Physiology \u201cRichard Burian,\u201d Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-4055","authenticated-orcid":false,"given":"Marwa","family":"Yousef","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-7600","authenticated-orcid":false,"given":"\u00d6zge Selin","family":"Cevik","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-6644","authenticated-orcid":false,"given":"Cem","family":"Suer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-1116","authenticated-orcid":false,"given":"Leyla","family":"Sahin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.2023.2346.4"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3604","article-title":"Resocialization Mitigates Depressive Behaviors Induced by Social Isolation Stress in Mice: Attenuation of Hippocampal Neuroinflammation and Nitrite Level","volume":"14","author":"Amini\u2010Khoei H.","year":"2024","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2022.103270"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084261"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113630"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5016\/1806-8774.2010v12p30"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201002229\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010023\u201000710\u2010z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1256744"},{"key":"e_1_2_11_11_1","article-title":"Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice","volume":"53","author":"Bromley\u2010Brits K.","year":"2011","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91199-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2025.115481"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-09090.1999"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.03.029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1735180.590"},{"key":"e_1_2_11_17_1","unstructured":"Cusack K.2020. \u201cRegional and Developmental Profile of Hippocampal Neuroplasticity in Adolescence: Lessons From Animal Studies.\u201d MRes Thesis University College Cork."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.03.046"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114433"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100367"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5708"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41684-024-01471-7"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.08.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165071"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-018-4125-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-022-01297-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-022-00989-y"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106282"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2021.1923406"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666231005090134"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-03078-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121386"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12488-9"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4274\/ArchEpilepsy.2023.23094"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1202349"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104549"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0295855"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83660"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126866"},{"issue":"4","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41684-022-00950-z","article-title":"Stress and Feeding Behavior in Mice","volume":"51","author":"Le Bras A.","year":"2022","journal-title":"Laboratory Animals"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16816"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.01.017"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06013-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01216-x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136301"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2020-0077"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010084"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.02.006"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1975.38.2.356"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2023.2257444"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-021-01856-w"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.2040366.183"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-022-01294-4"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.07.004"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.02.011"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16010054"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.12.155"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.872628"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbad098"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-021-00184-y"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2019.65.2.10"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010021\u201000540\u2010x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15243525"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200583"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00826"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05326-9"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01490-3"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20039-w"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1132121"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.846315"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-95-0066-6_7"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2025.107647"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128134"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23292"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07132-4"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01835-w"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10307"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13191608"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00584-6"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2045-z"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00208"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796021000135"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.70177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jdn.70177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jdn.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:19:59Z","timestamp":1790140799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jdn.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jdn.70177"],"URL":"https:\/\/doi.org\/10.1002\/jdn.70177","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2026-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}