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Tg and F344\/NHsd wildtype (WT) rats were allowed to self\u2010administer intrajugular cocaine. For the first 7 sessions, neither genotype self\u2010administered cocaine (0.1\u2009mg\/kg\/infusion) on a fixed ratio 1 schedule. We thus implemented a lever\u2013cocaine \u201cautoshaping\u201d session followed by a series of manipulations changing dose and reinforcement schedule. Tg rats self\u2010administered much less cocaine than WT rats throughout the study. Of 8 Tg rats, 5 modestly increased self\u2010administration from sessions 36\u201350. Of those, only 3 showed a lever discrimination. Of 10 WT rats, 8 acquired robust self\u2010administration by session 19; all WT rats self\u2010administered cocaine by the end of the study. WT and Tg rats had similar baseline locomotor activity in the self\u2010administration chamber suggesting that the low levels of cocaine intake in the Tg rats did not reflect a nonspecific motor impairment in this rat strain. Concomitant measurement of activity with self\u2010administration revealed activity increases that followed increased cocaine intake. That relation held in Tg rats. Therefore, the present study provides evidence that HIV\u20101 Tg rats are less sensitive to the reinforcing effects of cocaine than their F344 WT counterparts.<\/jats:p>","DOI":"10.1002\/jeab.586","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T09:23:59Z","timestamp":1582190639000},"page":"468-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Male HIV\u20101 transgenic rats show reduced cocaine\u2010maintained lever\u2010pressing compared to F344 wildtype rats despite similar baseline locomotion"],"prefix":"10.1002","volume":"113","author":[{"given":"Y. 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