{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:32:07Z","timestamp":1780389127702,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA026946"],"award-info":[{"award-number":["R01DA026946"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA007027"],"award-info":[{"award-number":["T32DA007027"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UH3DA041146"],"award-info":[{"award-number":["UH3DA041146"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exper Analysis Behavior"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Relapse within the context of a substance use disorder can be triggered by cues that function as discriminative stimuli to signal contingencies of drug availability and promote drug\u2010taking behavior. Extinction procedures can weaken this association between drug\u2010associated cues and drug\u2010taking behavior and may reduce the probability of relapse. This study evaluated a regimen of extinction training on cocaine and heroin self\u2010administration in rhesus monkeys under a drug\u2010vs\u2010food choice procedure. Behavior was initially maintained under a concurrent schedule of food (1\u2010g food pellets; fixed\u2010ratio 100 schedule) and cocaine injections (0\u20130.1\u2009mg\/kg\/injection; fixed\u2010ratio 10) (n\u00a0=\u00a04 males) or heroin injections (0\u20130.01\u2009mg\/kg\/injection; fixed\u2010ratio 10) (n\u00a0=\u00a03 females and 1 male) during daily 2\u2010hr choice sessions. Subsequently, choice sessions were supplemented by daily 20\u2010hr saline self\u2010administration sessions for 14 consecutive days. During saline self\u2010administration sessions, only drug\u2010associated discriminative stimuli were presented and responding produced saline injections. Drug continued to be available during choice sessions. Prior to extinction training, both cocaine and heroin maintained dose\u2010dependent increases in drug\u2010vs\u2010food choice. Exposure to 14 saline self\u2010administration sessions failed to significantly decrease drug choice and increase food choice. These preclinical results do not support the effectiveness of extinguishing drug\u2010associated discriminative stimuli as a nonpharmacological treatment strategy for reducing drug choice.<\/jats:p>","DOI":"10.1002\/jeab.734","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T11:11:16Z","timestamp":1641467476000},"page":"505-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Contextual extinction of drug\u2010associated discriminative stimuli fails to attenuate drug\u2010vs\u2010food choice in rhesus monkeys"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-5246","authenticated-orcid":false,"given":"Matthew L.","family":"Banks","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Virginia Commonwealth University  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-5574","authenticated-orcid":false,"given":"Blake A.","family":"Hutsell","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Virginia Commonwealth University  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-645X","authenticated-orcid":false,"given":"S. Stevens","family":"Negus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Virginia Commonwealth University  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32834d63ac"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.08.005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.193"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.025"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.114.1.80"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01546-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.107859"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1901\/jaba.1991.24-657"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12337"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108369"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00014.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.073411"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01670.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.03.023"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000191"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200002000-00010"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00950-y"},{"key":"e_1_2_5_19_1","first-page":"331","volume-title":"Choice over time","author":"Herrnstein R.","year":"1992"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112899"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.11.003"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.12.026"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.05.021"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.45"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.05.022"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44427"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.09.020"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244304"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245115"},{"key":"e_1_2_5_30_1","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300096"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2266-7"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14735"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988119801200103"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(90)90045-Y"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0250-x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/xan0000061"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2016.10.006"},{"issue":"1","key":"e_1_2_5_39_1","first-page":"88","article-title":"Validation of a body condition scoring system in rhesus macaques (Macaca mulatta): Assessment of body composition by using dual\u2010energy x\u2010ray absorptiometry","volume":"51","author":"Summers L.","year":"2012","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeab.15"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0385-9"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108348"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.107848"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2021.109110"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1511480"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-36-11461.2003"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1971.15-73"},{"issue":"5","key":"e_1_2_5_48_1","first-page":"309","article-title":"The effects of lithium on choice between cocaine and food in the rhesus monkey","volume":"3","author":"Woolverton W. L.","year":"1979","journal-title":"Communications in Psychopharmacology"}],"container-title":["Journal of the Experimental Analysis of Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeab.734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jeab.734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jeab.734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:02:38Z","timestamp":1692975758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jeab.734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jeab.734"],"URL":"https:\/\/doi.org\/10.1002\/jeab.734","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/753699","asserted-by":"object"}]},"ISSN":["0022-5002","1938-3711"],"issn-type":[{"value":"0022-5002","type":"print"},{"value":"1938-3711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"2021-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}