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Brain regions implicated in drug and non\u2010drug\u2010related behaviors often overlap, complicating investigations of neurobiological mechanisms underlying SUDs. Here we presented a within\u2010subject model for studying self\u2010administration, reinforcer competition, extinction, and cued reinstatement of cocaine\u2010 and food\u2010seeking in rats. Due to differences in cocaine\u2010 and food\u2010reinforced behavior, we transformed data to proportions of baseline, revealing increased resistance to extinction and disproportionately greater cued reinstatement of cocaine seeking relative to food seeking. Consistent with previous reports, females showed greater preference for cocaine reinforcement than males, though these findings failed to reach statistical significance. To demonstrate the model's utility for investigating neurobiological mechanisms, we included proof\u2010of\u2010concept calcium imaging data demonstrating the utility of the behavioral model for detecting cellular activity patterns associated with cocaine\u2010 and food\u2010seeking behaviors. Future studies utilizing this model should improve understanding of the development and expression of pathological behaviors characteristic of SUDs in humans, sex differences in these behaviors, and their neurobiological correlates. Thus, the model has utility for improving understanding of SUDs, leading to novel treatments to reduce the pathological behaviors associated with SUDs.<\/jats:p>","DOI":"10.1002\/jeab.752","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T08:14:34Z","timestamp":1647504874000},"page":"457-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug versus non\u2010drug behaviors: A dual\u2010reward model of sex differences and neurobiological mechanisms in rats"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-5023","authenticated-orcid":false,"given":"Rusty W.","family":"Nall","sequence":"first","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina"},{"name":"Department of Psychology Jacksonville State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-6359","authenticated-orcid":false,"given":"Reda M.","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-0119","authenticated-orcid":false,"given":"Peter W.","family":"Kalivas","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12941"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.014"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.028"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4773-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12629"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association(2013).Diagnostic and statistical manual of mental disorders(p.991). 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