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Schedule\u2010induced polydipsia (SIP) is highly automated behavior, reliably occurring under intermediate interval schedules of reinforcement. The effect of putamen inhibition in mediating SIP of water and ethanol (4% w\/v) under a Fixed Time 5\u2010min (FT\u20105\u2009min) schedule for food delivery was tested in 12 rhesus monkeys (6 male, 6 female). Water and ethanol SIP sessions ended after set volumes were consumed. Baseline patterns of SIP intake differed between water and ethanol SIP in volume but not in pattern of drinking. Activation of the designer receptor exclusively activated by designer drug (DREADD: hM4Di) with deschloroclozapine (DCZ; 300\u2009\u03bcg\/kg, i.m.) administered 30\u2009min prior to the onset of the SIP session, for four consecutive sessions. DCZ administration increased the postpellet drink volume and reduced the time to drink both water and ethanol. Although the effect of DCZ treatment was similar for increasing SIP with either water or ethanol, post\u2010DCZ return to baseline SIP rates of differed, perhaps highlighting the effect of a state dependency with ethanol SIP. Overall, the study shows that targeting the putamen with the inhibitory DREADD produces a reversible, reproducible and reliable increase in adjunctive drinking.<\/jats:p>","DOI":"10.1002\/jeab.761","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T11:41:09Z","timestamp":1649763669000},"page":"493-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of putamen inhibition by<scp>DREADDs<\/scp>on schedule\u2010induced drinking in rhesus monkeys"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-7219","authenticated-orcid":false,"given":"Kathleen A.","family":"Grant","sequence":"first","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University Beaverton"},{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University Portland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-9673","authenticated-orcid":false,"given":"Natali N.","family":"Newman","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University Beaverton"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University Beaverton"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-3241","authenticated-orcid":false,"given":"Verginia C.","family":"Cuzon Carlson","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University Beaverton"},{"name":"Department of Behavioral Neuroscience Oregon Health &amp; Science University Portland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01181-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700293104"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13327"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.131"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1475-20.2020"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1972.17-395"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.12.010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.140"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(85)90111-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90209-5"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03209574"},{"key":"e_1_2_5_14_1","first-page":"335","volume-title":"Analysis and integration of behavioral units","author":"Falk J. 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