{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:29:11Z","timestamp":1771626551265,"version":"3.50.1"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,15]],"date-time":"2002-03-15T00:00:00Z","timestamp":1016150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenomedullin (AM), \u03b1\u2010 and \u03b2\u2010calcitonin gene\u2010related peptide (CGRP), calcitonin (CT), and amylin are homologous polypeptides with overlapping biological actions such as vasodilatation and inhibition of bone resorption. They are brought about through receptors that include the CT receptor (CTR) and an initially orphan CT receptor\u2010like receptor (CRLR) in association with receptor\u2010activity\u2010modifying proteins (RAMP)1, \u20102, and \u20103. Co\u2010expression of CRLR with RAMP1 or \u20102 revealed CGRP or AM receptors, respectively. The CTR interacts with CT and does not require a known RAMP for functional expression. The same CTR is a CGRP\/amylin or an amylin receptor upon co\u2010expression with RAMP1 or \u20103, respectively. Interactions between CRLR and RAMP are thought to be required for their delivery to the cell surface. There, heterodimeric complexes between CRLR or CTR and the corresponding RAMP reveal high\u2010affinity receptors for AM, CGRP, and amylin. Here we review the current knowledge on interactions of G protein\u2010coupled receptors with defined associated proteins. Microsc. Res. Tech. 57:14\u201322, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.10051","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:13:41Z","timestamp":1030302821000},"page":"14-22","source":"Crossref","is-referenced-by-count":18,"title":["Functional interaction of G protein\u2010coupled receptors of the adrenomedullin peptide family with accessory receptor\u2010activity\u2010modifying proteins (RAMP)"],"prefix":"10.1002","volume":"57","author":[{"given":"Walter","family":"Born","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Muff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,15]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.19.11325"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.12.5377"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01387-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2994212"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(00)00074-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.3.6541"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(91)90218-E"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(25)06943-1","article-title":"Calcitonin gene\u2010related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance","volume":"48","author":"Bell D","year":"1996","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77991-6_16"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(95)00125-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.6.6783"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02259-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702975"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90230-O"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1124\/mol.52.6.1164","article-title":"Expression cloning and receptor pharmacology of human calcitonin receptors from MCF\u20107 cells and their relationship to amylin receptors","volume":"52","author":"Chen W\u2010J","year":"1997","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)08983-1"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.20.7763"},{"key":"e_1_2_1_21_1","first-page":"17","article-title":"Evidence for a new parathyroid hormone which lowers blood calcium","volume":"4","author":"Copp DH","year":"1961","journal-title":"Can Fed Biol Soc"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92391-7"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-3565(25)20868-0","article-title":"Structure\u2010activity profile of calcitonin gene\u2010related peptide in peripheral and brain tissues. 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