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Adaptation to hypoxia involves changes in the expression of various CB genes, whose products are involved in the transduction and modulation of the hypoxic signal to the central nervous system (CNS). Genes encoding neurotransmitter\u2010synthesizing enzymes and receptors are particularly important in this regard. The cellular response to hypoxia correlates closely with the release and biosynthesis of catecholamines. The gene expression of tyrosine hydroxylase (TH), the rate\u2010limiting enzyme for catecholamine biosynthesis, is regulated by hypoxia in the CB and in the oxygen\u2010sensitive cultured PC12 cell line. Recently, genomic microarray studies have identified additional genes regulated by hypoxia. Patterns of gene expression vary, depending on the type of applied hypoxia, e.g., intermittent vs. chronic. Construction of a hypoxia\u2010regulated, CB\u2010specific, subtractive cDNA library will enable us to further characterize regulation of gene expression in the CB. Microsc. 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Tech. 59:178\u2013187, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.10192","type":"journal-article","created":{"date-parts":[[2002,10,17]],"date-time":"2002-10-17T15:56:14Z","timestamp":1034870174000},"page":"178-187","source":"Crossref","is-referenced-by-count":24,"title":["Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen\u2010sensitive neuroendocrine cells"],"prefix":"10.1002","volume":"59","author":[{"given":"Waltke R.","family":"Paulding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip O.","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin 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