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Functionally, the anterior acrosome is involved in the acrosome reaction or sperm\u2013zona pellucida interaction, while the equatorial segment (posterior acrosome) is involved in sperm\u2013egg fusion. The acrosome is formed during spermiogenesis, during which associated molecules are transported from the Golgi apparatus and organized. Many of the molecules thus arranged gradually become compartmentalized during sperm passage through the epididymis. Some of them are further modified during the fertilization process. The findings indicate that acrosomal molecules are not only restricted to a specific region (domain) of the acrosome but also undergo ongoing relocation in a stage\u2010specific manner during sperm maturation in the testis and epididymis. Such maturation\u2010associated modifications are considered essential for sperm molecules to reach the correct or final site before fertilization. This review focuses on the organization and modifications of the acrosomal molecules as well as their compartmentalization within the acrosome. Microsc. Res. Tech. 61:39\u201345, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.10315","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T07:54:08Z","timestamp":1048838048000},"page":"39-45","source":"Crossref","is-referenced-by-count":66,"title":["Organization and modifications of sperm acrosomal molecules during spermatogenesis and epididymal maturation"],"prefix":"10.1002","volume":"61","author":[{"given":"Kazuya","family":"Yoshinaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Toshimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/jcs.108.2.767","article-title":"Monoclonal antibodies which recognize equatorial segment epitopes presented de novo following 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