{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:06:46Z","timestamp":1790651206347,"version":"4.1.0"},"reference-count":225,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T00:00:00Z","timestamp":1052092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peroxisomes are single membrane\u2010bound cell organelles performing numerous metabolic functions. The present article aims to give an overview of our current knowledge about inherited peroxisomal disorders in which these organelles are lacking or one or more of their functions are impaired. They are multiorgan disorders and the nervous system is implicated in most. After a summary of the historical names and categories, each having distinct symptoms and prognosis, microscopic pathology is reviewed in detail. Data from the literature are added to experience in the authors' laboratory with 167 liver biopsy and autopsy samples from peroxisomal patients, and with a smaller number of chorion samples for prenatal diagnosis, adrenal\u2010, kidney\u2010, and brain samples. Various light and electron microscopic methods are used including enzyme\u2010 and immunocytochemistry, polarizing microscopy, and morphometry. Together with other laboratory investigations and clinical data, this approach continues to contribute to the diagnosis and further characterization of peroxisomal disorders, and the discovery of novel variants. When liver specimens are examined, three main groups including 9 novel variants (33 patients) are distinguished: (1) absence or (2) presence of peroxisomes, and (3) mosaic distribution of cells with and without peroxisomes (10 patients). Renal microcysts, polarizing trilamellar inclusions, and insoluble lipid in macrophages in liver, adrenal cortex, brain, and in interstitial cells of kidney are also valuable for classification. On a genetic basis, complementation of fibroblasts has classified peroxisome biogenesis disorders into 12 complementation groups. Peroxisome biogenesis genes (<jats:italic>PEX<\/jats:italic>), knock\u2010out\u2010mice, and induction of redundant genes are briefly reviewed, including some recent results with 4\u2010phenylbutyrate. Finally, regulation of peroxisome expression during development and in cell cultures, and by physiological factors is discussed. Microsc. Res. Tech. 61:203\u2013223, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.10330","type":"journal-article","created":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T16:01:39Z","timestamp":1052150499000},"page":"203-223","source":"Crossref","is-referenced-by-count":57,"title":["Human peroxisomal disorders"],"prefix":"10.1002","volume":"61","author":[{"given":"Marianne","family":"Depreter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Espeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Roels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,5,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.5.1789"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.77"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-49"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001994200"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80209-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1626-4_6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440505"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200001)47:1<109::AID-ANA18>3.0.CO;2-P"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01800481"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90225-N"},{"key":"e_1_2_1_12_1","first-page":"402","article-title":"A familial syndrome of multiple congenital anomalies","volume":"114","author":"Bowen P","year":"1964","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.2.239"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00824339"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308478"},{"key":"e_1_2_1_16_1","first-page":"11","article-title":"Effects of marine oil diet on peroxisomes and mitochondria of rat liver. 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