{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:50Z","timestamp":1760644970334},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":5179,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Elec. Microsc. Tech."],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immature mammalian oocytes reside in ovarian follicles with junctionally coupled granulosa cells. When released from a currently undefined meiotic arresting influence, these oocytes resume meiosis to progress from late diplotene (germinal vesicle stage) through the first meiotic division to metaphase II. Oocytes remain at metaphase II until fertilization activates them to complete meiosis. This review summarizes ultrastructural events that occur during meiotic maturation in mammals. Developmental correlates that promise a clearer understanding of regulatory mechanisms operating to control maturation are emphasized. By use of TEM of thin sections, freeze\u2010fracture analysis, and replicated oocyte cortical patches, we demonstrate stage\u2010specific changes in the oocyte nucleus, reorganization of cytoplasmic organelles, correlations between oocyte maturational commitment and the junctional integrity of associated granulosa cells, and definition of the components comprising the oocyte cortical cytoplasm.<\/jats:p>","DOI":"10.1002\/jemt.1060160402","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T08:43:24Z","timestamp":1109234604000},"page":"257-280","source":"Crossref","is-referenced-by-count":14,"title":["Ultrastructural correlates of meiotic maturation in mammalian oocytes"],"prefix":"10.1002","volume":"16","author":[{"given":"Robert W.","family":"McGaughey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Racowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendall","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyce A.","family":"DeMarais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.97.5.1452"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.63.1.234"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.71.2.680"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90473-0"},{"key":"e_1_2_1_6_1","first-page":"241","volume-title":"Oogenesis","author":"Biggers J. D.","year":"1972"},{"key":"e_1_2_1_7_1","first-page":"365","volume-title":"Ovarian Follicular Development and Function","author":"Biggers J. D.","year":"1979"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141943"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/jcs.10.2.369","article-title":"Germinal vesicle breakdown in the mouse oocyte","volume":"10","author":"Calarco P. G.","year":"1972","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_10_1","unstructured":"Capco D. G. andLarabell C. A.(1989) The cytoskeleton as an organizer of RNA and protein during early development. In:Progress in Molecular and Subcellular Biology. In Press."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90265-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0740237"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120110311"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4369"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90160-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.74.1.153"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(82)90314-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(75)90011-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.78.1.58"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(73)90411-4"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90415-2"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0770425"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0760645"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.91.3.131s"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120080105"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(80)80034-1"},{"issue":"3","key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0040-8166(16)30351-2","article-title":"Origin and fate of cytoplasmic gap junctional vesicles in rabbit granulosa cells","volume":"10","author":"Larsen W. J.","year":"1978","journal-title":"Tissue Cell"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod25.5.1119"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90187-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90332-0"},{"key":"e_1_2_1_31_1","first-page":"211","article-title":"Localization of cytoskeletal proteins in preimplantation mouse embryos","volume":"55","author":"Lehtonen E.","year":"1980","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(85)90320-3"},{"key":"e_1_2_1_33_1","first-page":"11","article-title":"Mechanism of polar body formation in the mouse oocyte: An interaction between the chromosomes, the cytoskeleton and the plasma membrane","volume":"92","author":"Maro B.","year":"1986","journal-title":"J. Embrol. Exp. Morphol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61464-3"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90040-4"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-201850-3.50006-1"},{"key":"e_1_2_1_37_1","first-page":"106","volume-title":"Oxford Reviews of Reproductive Biology","author":"McGaughey R. W.","year":"1983"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402340119"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","unstructured":"McGaughey R. W. andCapco D. G.(1989) Specialized cytoskeletal elements in mammalian eggs: Structural and biochemical evidence for their composition.Cell Motil. in press.","DOI":"10.1002\/cm.970130205"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402090206"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401760402"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90267-6"},{"key":"e_1_2_1_43_1","first-page":"3","volume-title":"Development in Mammals","author":"Moor R. M.","year":"1980"},{"key":"e_1_2_1_44_1","first-page":"347","article-title":"Selective effect of gonadotrophins on cell coupling, nuclear maturation and protein synthesis in mammalian oocytes","volume":"61","author":"Moor R. M.","year":"1981","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0760031"},{"key":"e_1_2_1_46_1","first-page":"605a","article-title":"Cytoskeletal organization during early development in the mouse","volume":"107","author":"Mutchler D. V.","year":"1988","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_47_1","first-page":"254","article-title":"I ponti intercellulari trail novo ovarice e le cellule follicolari, e la formazione della zona pellucida","volume":"5","author":"Paladino G.","year":"1890","journal-title":"Anat. Anz."},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402170312"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.62.5.665"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0720107"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0740009"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402390214"},{"key":"e_1_2_1_53_1","first-page":"244","article-title":"Down\u2010regulation of membrane granulosa cell gap junctions is correlated with irreversible commitment to resume meiosis in golden Syrian hamster oocytes","volume":"49","author":"Racowsky C.","year":"1989","journal-title":"J. Eur. J. Cell Biol."},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(85)90022-3"},{"key":"e_1_2_1_55_1","first-page":"283","article-title":"Decreases in heterologous metabolic and dye coupling, but not in electrical coupling, accompany meiotic resumption in hamster oocyte\u2010cumulus complexes","volume":"43","author":"Racowsky C.","year":"1987","journal-title":"Eur. J. Cell Biol."},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1242\/jcs.76.1.17","article-title":"Shape dependent regulation of cytoskeletal protein synthesis in anchorage\u2010dependent and anchorage\u2010independent cells","volume":"76","author":"Reiter T.","year":"1985","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0620245"},{"key":"e_1_2_1_59_1","first-page":"22","article-title":"Meiotic arresting action of the substance obtained from the cell surface of porcine ovarian cells","volume":"48","author":"Sato E.","year":"1977","journal-title":"Jpn. J. Zootech. Sci."},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.2.538"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.5.2.327"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091590412"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68800-3_3"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19780323"},{"key":"e_1_2_1_65_1","first-page":"181","article-title":"Ultrastructural aspects of fertilization in the domestic pig: Sperm penetration and pronucleus formation","volume":"116","author":"Sz\u00f6ll\u00f6si D.","year":"1973","journal-title":"J. Anat."},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-4-922"},{"key":"e_1_2_1_67_1","first-page":"67","volume-title":"Control of Cell Growth and Proliferation","author":"Van Blerkom J.","year":"1985"},{"key":"e_1_2_1_68_1","first-page":"33","volume-title":"Development of Preimplantation Embryos and Their Environment","author":"Van Blerkom J.","year":"1989"},{"key":"e_1_2_1_69_1","first-page":"213","article-title":"Regulation of development in the fully grown mouse oocyte: Chromosome\u2010mediated temporal and spatial differentiation of the cytoplasm and plasma membrane","volume":"93","author":"Van Blerkom J.","year":"1986","journal-title":"J. Embrol. Exp. Morphol."},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(78)90120-3"},{"key":"e_1_2_1_71_1","first-page":"178","volume-title":"The Cellular Basis of Mammalian Reproduction","author":"Van Blerkom J.","year":"1979"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001710309"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/261073a0"},{"key":"e_1_2_1_74_1","first-page":"178a","article-title":"Cytoskeletal interactions between the sperm and egg at penetration in the Syrian hamster","volume":"107","author":"Webster S. D.","year":"1988","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.81.3.624"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120220204"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(79)80024-6"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod2.Supplement_2.44"}],"container-title":["Journal of Electron Microscopy Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.1060160402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.1060160402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T19:37:14Z","timestamp":1698003434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jemt.1060160402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1002\/jemt.1060160402"],"URL":"https:\/\/doi.org\/10.1002\/jemt.1060160402","archive":["Portico"],"relation":{},"ISSN":["0741-0581","1553-0817"],"issn-type":[{"value":"0741-0581","type":"print"},{"value":"1553-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}