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Detailed analysis of meiotically mature preovulatory (uninseminated) oocytes, and of oocytes that failed to fertilize in vitro, indicated that between 10% and 15% of grossly normal\u2010appearing MII\u2010stage oocytes displayed one of the following cellular perturbations: (1) a subtle change in organelle distribution, (2) a small region(s) of intracellular cytolysis, (3) a massive aggregation of SER tubules, (4) an accumulation of vesicles presumed to be of SER origin, (5) a change in the structural organization of the cortical cytoplasm and overlying plasma membrane, (6) a sudden and rapid internalization of perivitelline fluid by means of an apparently aberrant process of endocytosis, and (7) a premature and partial exocytosis of cortical granules. The description of these disorders is discussed with respect to the developmental consequences for the oocyte.<\/jats:p>","DOI":"10.1002\/jemt.1060160405","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T08:43:24Z","timestamp":1109234604000},"page":"324-346","source":"Crossref","is-referenced-by-count":101,"title":["Occurrence and developmental consequences of aberrant cellular organization in meiotically mature human oocytes after exogenous ovarian hyperstimulation"],"prefix":"10.1002","volume":"16","author":[{"given":"Jonathan","family":"Van Blerkom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/303336a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136621"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01134578"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/oxfordjournals.humrep.a136760","article-title":"Chromosome anomalies in human oocytes failing to fertilize after insemination in vitro","volume":"3","author":"Bongso A.","year":"1988","journal-title":"Hum. 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