{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:31:34Z","timestamp":1770499894566,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,3,23]],"date-time":"2001-03-23T00:00:00Z","timestamp":985305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chicken pinealocytes contain three major components of the circadian clock system: 1) a self\u2010sustained oscillator, 2) a photic\u2010input pathway to the oscillator, and 3) an overt output represented by the rhythmic production of melatonin. Even under cultured conditions of isolated pineal gland or dissociated pinealocytes, the input\u2010oscillator\u2010output functions are well maintained. Because of these experimental advantages, chicken pineal gland has been one of the best models for the study of the circadian clock system. Since the finding of a pineal\u2010specific photoreceptive molecule, pinopsin, we have characterized the endogenous phototransduction pathway in the pinealocytes. On the other hand, despite the long history of chick pineal research, the molecular mechanism underlying the pineal clock oscillation has been largely unknown. Our recent characterization of the chick pineal clock genes strongly suggests that they constitute a transcription\/translation\u2010based autoregulatory feedback loop, which is very similar to that generating circadian rhythmicity in mammalian SCN. Microsc. Res. Tech. 53:72\u201380, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.1070","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:30:12Z","timestamp":1030296612000},"page":"72-80","source":"Crossref","is-referenced-by-count":35,"title":["Photoreception and circadian clock system of the chicken pineal 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