{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:41:00Z","timestamp":1760643660420,"version":"build-2065373602"},"reference-count":100,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4386,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>How are the axonal projections of olfactory and vomeronasal receptor neurons to the olfactory bulb formed during development? How are the primary olfactory axonal connections functionally organized? With progress in molecular biological techniques and histochemical methods, it became possible to study cellular strategies and molecular mechanisms which guide the primary olfactory axons of the main and accessory olfactory systems to the target glomeruli in the bulb. In addition, new methodologies have begun to elucidate various subsets of the primary olfactory axons with distinctive central connections. The aim of the present paper is to review (1) the characteristic organization of the projection of the primary olfactory axons, (2) projection patterns of histochemically defined subsets of primary olfactory axons, and (3) information on molecules expressed by the surface membrane of the primary olfactory axons. This knowledge gives insight into the functional organization of the primary olfactory axon projection, which is indispensable for understanding signal processing in the olfactory system. This knowledge also underscores the notion that the primary olfactory axon projection provides an excellent model system in which to study axonal guidance and the formation of specific synaptic connections. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.1070240205","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T17:35:46Z","timestamp":1109180146000},"page":"131-141","source":"Crossref","is-referenced-by-count":28,"title":["Molecular and cellular properties of mammalian primary olfactory axons"],"prefix":"10.1002","volume":"24","author":[{"given":"Kensaku","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1007\/978-1-4613-0989-5_13"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0012-1606(85)90465-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1523\/JNEUROSCI.05-02-00284.1985","article-title":"Identification of cell surface glycoprotein family of olfactory receptor neurons with a monoclonal antibody","volume":"5","author":"Allen W. K.","year":"1985","journal-title":"J. Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1093\/brain\/72.2.186"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1002\/cne.902890304"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1016\/0006-8993(81)90127-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1016\/0306-4522(89)90348-5"},{"key":"e_1_2_1_9_1","first-page":"365","volume-title":"Neural Growth and Differentiation","author":"Barber P. C.","year":"1979"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_1","DOI":"10.1016\/0166-2236(87)90135-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1002\/j.1460-2075.1985.tb04001.x","article-title":"Demonstration of immunochemical identity between the nerve growth factor\u2010inducible large external (NILE) glycoprotein and the cell adhesion molecule L1","volume":"4","author":"Bock E.","year":"1985","journal-title":"EMBO J."},{"doi-asserted-by":"publisher","key":"e_1_2_1_12_1","DOI":"10.1016\/0092-8674(91)90418-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_1","DOI":"10.1152\/jn.1990.63.3.447"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_1","DOI":"10.1016\/S0166-2236(84)80061-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_1","DOI":"10.1007\/BF00215198"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_1","DOI":"10.1126\/science.3576199"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1523\/JNEUROSCI.05-12-03278.1985","article-title":"Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to superficial dorsal horn of rat spinal cord","volume":"5","author":"Dodd J.","year":"1985","journal-title":"J. Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_18_1","DOI":"10.1126\/science.3055291"},{"doi-asserted-by":"publisher","key":"e_1_2_1_19_1","DOI":"10.1038\/311469a0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_20_1","DOI":"10.1146\/annurev.ne.07.030184.002011"},{"doi-asserted-by":"publisher","key":"e_1_2_1_21_1","DOI":"10.1016\/0165-3806(85)90192-0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_22_1","DOI":"10.1083\/jcb.102.2.413"},{"doi-asserted-by":"publisher","key":"e_1_2_1_23_1","DOI":"10.1016\/0921-8696(91)90860-P"},{"doi-asserted-by":"publisher","key":"e_1_2_1_24_1","DOI":"10.1016\/0006-8993(85)91403-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_25_1","DOI":"10.1085\/jgp.39.4.473"},{"doi-asserted-by":"publisher","key":"e_1_2_1_26_1","DOI":"10.1016\/0165-3806(89)90072-2"},{"key":"e_1_2_1_27_1","first-page":"27","volume-title":"Handbook of Sensory Physiology","author":"Graziadei P. P. C.","year":"1971"},{"doi-asserted-by":"publisher","key":"e_1_2_1_28_1","DOI":"10.1007\/978-3-642-66880-7_2"},{"key":"e_1_2_1_29_1","first-page":"131","volume-title":"Neuronal Plasticity","author":"Graziadei P. P. C.","year":"1978"},{"doi-asserted-by":"publisher","key":"e_1_2_1_30_1","DOI":"10.1016\/0306-4522(86)90119-3"},{"doi-asserted-by":"publisher","key":"e_1_2_1_31_1","DOI":"10.1073\/pnas.75.10.5230"},{"doi-asserted-by":"publisher","key":"e_1_2_1_32_1","DOI":"10.1016\/0306-4522(79)90002-2"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1523\/JNEUROSCI.02-12-01744.1982","article-title":"Functional development of the olfactory bulb and a unique glomerular complex in the neonatal rat","volume":"2","author":"Greer C. A.","year":"1982","journal-title":"J. Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_34_1","DOI":"10.1126\/science.3187519"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1523\/JNEUROSCI.05-02-00438.1985","article-title":"A panel of monoclonal antibody to the rat olfactory epithelium","volume":"5","author":"Hempsread J. L.","year":"1985","journal-title":"J. Neurosci."},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1523\/JNEUROSCI.05-09-02382.1985","article-title":"Monoclonal antibodies reveal novel aspects of the biochemistry and organization of olfactory neurons following unilateral olfactory bulbectomy","volume":"5","author":"Hempsread J. L.","year":"1985","journal-title":"J. Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_37_1","DOI":"10.1002\/cne.901460208"},{"doi-asserted-by":"publisher","key":"e_1_2_1_38_1","DOI":"10.1038\/282720a0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_39_1","DOI":"10.1007\/978-1-4757-5955-6_11"},{"doi-asserted-by":"publisher","key":"e_1_2_1_40_1","DOI":"10.1016\/0092-8674(92)90472-O"},{"doi-asserted-by":"publisher","key":"e_1_2_1_41_1","DOI":"10.1016\/0006-8993(85)91050-9"},{"doi-asserted-by":"crossref","unstructured":"Imamura K. Mataga N. andMori K.(1992) Coding of odor molecules by mitral\/tufted cells in rabbit olfactory bulb. I. Aliphatic compounds.J. Neurophysiol. in press.","key":"e_1_2_1_42_1","DOI":"10.1152\/jn.1992.68.6.1986"},{"doi-asserted-by":"publisher","key":"e_1_2_1_43_1","DOI":"10.1098\/rstb.1985.0027"},{"doi-asserted-by":"publisher","key":"e_1_2_1_44_1","DOI":"10.1146\/annurev.ne.13.030190.001303"},{"doi-asserted-by":"publisher","key":"e_1_2_1_45_1","DOI":"10.1016\/0006-8993(80)90563-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_46_1","DOI":"10.1002\/j.1460-2075.1983.tb01746.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_47_1","DOI":"10.1002\/ar.1092000313"},{"doi-asserted-by":"publisher","key":"e_1_2_1_48_1","DOI":"10.1016\/0166-2236(91)90025-P"},{"doi-asserted-by":"publisher","key":"e_1_2_1_49_1","DOI":"10.1016\/0306-4522(86)90171-5"},{"doi-asserted-by":"publisher","key":"e_1_2_1_50_1","DOI":"10.1016\/0304-3940(86)90591-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_51_1","DOI":"10.1146\/annurev.ne.09.030186.001553"},{"doi-asserted-by":"publisher","key":"e_1_2_1_52_1","DOI":"10.1073\/pnas.79.2.670"},{"doi-asserted-by":"publisher","key":"e_1_2_1_53_1","DOI":"10.1016\/0166-2236(89)90070-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_54_1","DOI":"10.1016\/0306-4522(85)90009-0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_55_1","DOI":"10.1016\/0012-1606(88)90397-1"},{"doi-asserted-by":"publisher","key":"e_1_2_1_56_1","DOI":"10.1016\/0012-1606(89)90179-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_57_1","DOI":"10.1016\/0165-3806(85)90154-3"},{"doi-asserted-by":"publisher","key":"e_1_2_1_58_1","DOI":"10.1007\/978-1-4684-4685-2_6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_59_1","DOI":"10.1038\/334701a0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_60_1","DOI":"10.1007\/978-1-4613-0989-5_12"},{"doi-asserted-by":"publisher","key":"e_1_2_1_61_1","DOI":"10.1002\/cne.902420205"},{"doi-asserted-by":"publisher","key":"e_1_2_1_62_1","DOI":"10.1016\/0006-8993(86)91659-8"},{"doi-asserted-by":"publisher","key":"e_1_2_1_63_1","DOI":"10.1016\/0301-0082(87)90024-4"},{"key":"e_1_2_1_64_1","first-page":"320","article-title":"Organization of olfactory pathways","volume":"31","author":"Mori K.","year":"1987","journal-title":"Sinkei\u2010Kenkyu no Shinpo (Adv. Neurol. Scie.)"},{"doi-asserted-by":"publisher","key":"e_1_2_1_65_1","DOI":"10.1016\/0006-8993(87)90375-1"},{"doi-asserted-by":"publisher","key":"e_1_2_1_66_1","DOI":"10.1016\/0306-4522(87)90018-2"},{"key":"e_1_2_1_67_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1152\/jn.1992.67.3.786","article-title":"Differential specificities of single mitral cells in rabbit olfactory bulb for a homologous series of fatty acid odor molecules","volume":"67","author":"Mori K.","year":"1992","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_68_1","first-page":"134","volume-title":"ISOT X, Proceedings of the Tenth International Symposium on Olfaction and Taste","author":"Mori K.","year":"1990"},{"key":"e_1_2_1_69_1","first-page":"20","volume-title":"Olfaction and Taste IV, Proceedings of the Fourth International Symposium","author":"Moulton D. G.","year":"1972"},{"key":"e_1_2_1_70_1","first-page":"327","volume-title":"Medical Physiology","author":"Mountcastle V. B.","year":"1980"},{"doi-asserted-by":"publisher","key":"e_1_2_1_71_1","DOI":"10.1016\/0014-4827(86)90453-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_72_1","DOI":"10.1016\/0306-4522(88)90115-7"},{"doi-asserted-by":"publisher","key":"e_1_2_1_73_1","DOI":"10.1016\/0306-4522(88)90116-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_74_1","DOI":"10.1242\/jcs.9.2.347"},{"key":"e_1_2_1_75_1","first-page":"261","article-title":"Cosegregation of monoclonal antibody reactivity and cell behavior in the mouse preimplantation embryo","volume":"70","author":"Randle B. J.","year":"1982","journal-title":"J. Embryol. Exp. Morphol."},{"doi-asserted-by":"publisher","key":"e_1_2_1_76_1","DOI":"10.1002\/cne.902200108"},{"doi-asserted-by":"publisher","key":"e_1_2_1_77_1","DOI":"10.1002\/cne.902700409"},{"doi-asserted-by":"publisher","key":"e_1_2_1_78_1","DOI":"10.1146\/annurev.bi.57.070188.002111"},{"key":"e_1_2_1_79_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1152\/physrev.1988.68.3.819","article-title":"Cell adhesion molecules in vertebrate neural development","volume":"68","author":"Rutishauser U.","year":"1988","journal-title":"Physiol. Rev."},{"doi-asserted-by":"publisher","key":"e_1_2_1_80_1","DOI":"10.1016\/0006-8993(91)90967-Z"},{"key":"e_1_2_1_81_1","first-page":"497","article-title":"Expression of carbohydrate antigens in rat olfactory cell cultures","volume":"16","author":"Schwarting G. A.","year":"1990","journal-title":"Soc. Neurosci. Abst."},{"key":"e_1_2_1_82_1","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1523\/JNEUROSCI.06-11-03393.1986","article-title":"The primary olfactory projection has two chemically distinct zones","volume":"6","author":"Schwob J. E.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_83_1","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1523\/JNEUROSCI.08-09-03470.1988","article-title":"Purification and characterization of an antigen that is spatially segregated in the primary olfactory projection","volume":"8","author":"Schwob J. E.","year":"1988","journal-title":"J. Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_84_1","DOI":"10.1523\/JNEUROSCI.06-01-00208.1986"},{"doi-asserted-by":"publisher","key":"e_1_2_1_85_1","DOI":"10.1152\/physrev.1972.52.4.864"},{"key":"e_1_2_1_86_1","first-page":"209","volume-title":"Brain Mechanisms of Sensation","author":"Shepherd G. M.","year":"1981"},{"doi-asserted-by":"publisher","key":"e_1_2_1_87_1","DOI":"10.1016\/0960-9822(91)90056-3"},{"doi-asserted-by":"publisher","key":"e_1_2_1_88_1","DOI":"10.1016\/0092-8674(82)90274-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_89_1","DOI":"10.1002\/cne.902840304"},{"key":"e_1_2_1_90_1","first-page":"103","article-title":"Lectins label subpopulations of olfactory receptor cells","volume":"16","author":"Stewart W. B.","year":"1990","journal-title":"Soc. Neurosci. Abst."},{"doi-asserted-by":"publisher","key":"e_1_2_1_91_1","DOI":"10.1007\/BF00305057"},{"doi-asserted-by":"publisher","key":"e_1_2_1_92_1","DOI":"10.1098\/rspb.1981.0067"},{"doi-asserted-by":"publisher","key":"e_1_2_1_93_1","DOI":"10.1016\/0166-2236(89)90139-2"},{"key":"e_1_2_1_94_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1523\/JNEUROSCI.09-02-00683.1989","article-title":"The expression of the growth associated protein B50\/GAP43 in the olfactory system of neonatal and adult rats J","volume":"9","author":"Verhaagan J.","year":"1989","journal-title":"Neurosci."},{"doi-asserted-by":"publisher","key":"e_1_2_1_95_1","DOI":"10.1016\/0006-8993(73)90792-0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_96_1","DOI":"10.1146\/annurev.iy.06.040188.002121"},{"doi-asserted-by":"publisher","key":"e_1_2_1_97_1","DOI":"10.1073\/pnas.82.11.3906"},{"doi-asserted-by":"publisher","key":"e_1_2_1_98_1","DOI":"10.1016\/0006-8993(88)90522-7"},{"doi-asserted-by":"publisher","key":"e_1_2_1_99_1","DOI":"10.1016\/0168-0102(91)90008-M"},{"doi-asserted-by":"publisher","key":"e_1_2_1_100_1","DOI":"10.1016\/0168-0102(91)90033-U"},{"doi-asserted-by":"crossref","unstructured":"Yoshihara Y. Katoh K. andMori K.(1993) Odor stimulation causes disappearance of R4B12 epitope on axonal surface molecule of olfactory sensory neurons.Neurosci. in press.","key":"e_1_2_1_101_1","DOI":"10.1016\/0306-4522(93)90288-Q"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.1070240205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.1070240205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:01:16Z","timestamp":1760637676000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.1070240205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":100,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1002\/jemt.1070240205"],"URL":"https:\/\/doi.org\/10.1002\/jemt.1070240205","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"type":"print","value":"1059-910X"},{"type":"electronic","value":"1097-0029"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}