{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:59:30Z","timestamp":1778853570597,"version":"3.51.4"},"reference-count":97,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":4252,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[1993,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During blastocyst implantation and placentation in common laboratory rodents, trophoblast cells come into increasingly more intimate associations with the endometrium and, eventually, are in contact with maternal blood. Uterine cell death is one mechanism for removing uterine tissues, primarily epithelial cells, and decidual cells that intervene between trophoblast cells and maternal blood. Mechanisms of cell death and the signals that initiate and regulate it are not well understood. According to current theories, cell death is either gene\u2010directed or the result of traumatic injury, and classification of cell death is based on ultrastructural and biochemical criteria that hypothetically reflect underlying molecular mechanisms. Although the term apoptosis is extensively used to describe all aspects of gene\u2010directed cell death and the term necrosis to describe traumatic death, ultrastructural studies indicate that there are morphological variations of the established criteria, and these could reflect variations of underlying mechanisms. Recent light and electron microscopic work has shown that timing and ultrastructure of uterine cell death at the gestation site varies with region suggesting that initiation and control of cell death is complicated and that more than one mechanism of cell death may be operative. Current information indicates that uterine cell death is most likely part of an intrinsic response of the endometrium to the conceptus, and other than acting as a stimulus to elicit the uterine response, the conceptus probably plays only a minor role in regulating the death of endometrial cells in these species. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.1070250305","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T17:29:42Z","timestamp":1109179782000},"page":"223-245","source":"Crossref","is-referenced-by-count":41,"title":["Uterine cell death during implantation and early placentation"],"prefix":"10.1002","volume":"25","author":[{"given":"Alerick O.","family":"Welsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090880305"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61675-7"},{"key":"e_1_2_1_4_1","first-page":"220","volume-title":"Oxford Reviews of Reproductive Biology","author":"Bell S. C.","year":"1983"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0610425"},{"key":"e_1_2_1_6_1","first-page":"27","article-title":"Biology of the trophoblast","volume":"5","author":"Billington W. D.","year":"1971","journal-title":"Adv. Reprod. Physiol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1987.Supplement_8.18"},{"key":"e_1_2_1_8_1","volume-title":"Programmed Cell Death in Tumors and Tissues","author":"Bowen I. D.","year":"1990"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.8.3473"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281804"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00174615"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8326-0_32"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0190239"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320677"},{"key":"e_1_2_1_15_1","first-page":"191","volume-title":"Cellular Biology of the Uterus","author":"De Feo V. J.","year":"1967"},{"key":"e_1_2_1_16_1","first-page":"18","volume-title":"Perspectives on Mammalian Cell Death","author":"Dean R. T.","year":"1987"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(87)90016-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90152-0"},{"key":"e_1_2_1_19_1","first-page":"351","article-title":"Macrophage recognition of cells undergoing programmed cell death (apoptosis)","volume":"56","author":"Duvall E.","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_20_1","first-page":"643","article-title":"Cell redundancy in the zona\u2010intact preimplantation mouse blastocyst: A light and electron microscopic study of dead cells and their fate","volume":"31","author":"El\u2010Shershaby A. M.","year":"1974","journal-title":"J. Embryol. Exp. Morpho."},{"key":"e_1_2_1_21_1","first-page":"1067","article-title":"Epithelial autolysis during implantation of the mouse blastocyst: An ultrastructural study","volume":"33","author":"El\u2010Shershaby A. M.","year":"1975","journal-title":"J. Embryol. Exp. Morpho."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001200202"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3180-3_29"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990150304"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001120305"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0340247"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0080331"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(67)80102-3"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0860619"},{"key":"e_1_2_1_30_1","first-page":"17","volume-title":"Blastocyst Implantation","author":"Fleming S.","year":"1989"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402080309"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.4.1108"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1951.tb00774.x"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4049\/jimmunol.141.3.774","article-title":"Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes","volume":"141","author":"Gromkowski S. H.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-3371(90)90052-X"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0450463"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1948.tb07422.x"},{"key":"e_1_2_1_38_1","first-page":"66","volume-title":"Perspectives on Mammalian Cell Death","author":"Hume W. J.","year":"1987"},{"key":"e_1_2_1_39_1","first-page":"55","article-title":"Cell death in developing systems","volume":"13","author":"Hurle J. M.","year":"1988","journal-title":"Methods Achiev. Exp. Pathol."},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-2-659"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310059"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1710970314"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33"},{"key":"e_1_2_1_44_1","first-page":"93","volume-title":"Perspectives on Mammalian Cell Death","author":"Kerr J. F. R.","year":"1987"},{"key":"e_1_2_1_45_1","first-page":"64","volume-title":"Epithelial\u2010Mesenchymal Interactions","author":"Kirby D. R. S.","year":"1968"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod15.5.593"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod39.4.937"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400609"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod44.1.171"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.10.2.30160901"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.141.8.2629"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/45.5.B135"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-5-60"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1908.25310490025002d"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214688"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090650308"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod19.1.167"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001660304"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(89)90026-X"},{"key":"e_1_2_1_60_1","first-page":"211","article-title":"An ultrastructural study of implantation in the golden hamster. II. Trophoblastic invasion and removal of the uterine epithelium","volume":"122","author":"Parkening T. A.","year":"1976","journal-title":"J. Anat."},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod36.1.211"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod34.2.393"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5589-2_9"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74170-8_1"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0810249"},{"key":"e_1_2_1_66_1","first-page":"421","article-title":"An ultrastructural study of implanting mouse blastocysts: Coated vesicles and epithelium formation","volume":"119","author":"Poelmann R. E.","year":"1975","journal-title":"J. Anat."},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217324"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-1-86"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001560103"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.154.3749.604"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/343170a0"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod12.1.41"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092120107"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070306"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(79)90007-4"},{"key":"e_1_2_1_76_1","first-page":"227","volume-title":"The Developmental Biology of Reproduction","author":"Sherman M. I.","year":"1975"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218936"},{"key":"e_1_2_1_78_1","first-page":"167","article-title":"The differentiation of the decidua and the distribution of metrial gland cells in the pregnant mouse uterus","volume":"187","author":"Stewart I.","year":"1968","journal-title":"Cell Tissue Res."},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0210037"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(82)90147-6"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6921-9_8"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod35.4.1045"},{"key":"e_1_2_1_83_1","first-page":"3","article-title":"Some general observations on placentation with special reference to the theory of evolution","volume":"11","author":"Turner W.","year":"1876","journal-title":"J. Anat. Physiol."},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0490061"},{"key":"e_1_2_1_85_1","first-page":"18","article-title":"Patterns of cell death","volume":"13","author":"Walker N. I.","year":"1988","journal-title":"Methods Achiev. Exp. Pathol."},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00347020"},{"key":"e_1_2_1_87_1","first-page":"231","volume-title":"The Physiology of Reproduction","author":"Weitlauf H. M.","year":"1988"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001670405"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001720102"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092170213"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001920302"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001920404"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0050281"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90254-0"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.1.179"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/284555a0"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-6921-9_2"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62312-8"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.1070250305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.1070250305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:19:38Z","timestamp":1760624378000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.1070250305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,15]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,6,15]]}},"alternative-id":["10.1002\/jemt.1070250305"],"URL":"https:\/\/doi.org\/10.1002\/jemt.1070250305","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"value":"1059-910X","type":"print"},{"value":"1097-0029","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6,15]]}}}