{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:34:55Z","timestamp":1760661295851,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,4]],"date-time":"2005-02-04T00:00:00Z","timestamp":1107475200000},"content-version":"vor","delay-in-days":3765,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[1994,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In previous experiments, we have shown that antidepressants such as desipramine (DMI) can induce axonal regeneration of noradrenergic locus coeruleus neurons. In this article, we suggest that phospholipase A2 is involved in the molecular mechanism of the antidepressant\u2010induced regeneration of brain noradrenergic axons. The effects of the PLA2 inhibitors, mepacrine (MEP) or 4\u2010bromphenacyl bromide (BPB), upon the DMI\u2010induced regeneration of noradrenergic axons in the rat cerebral cortex were assessed by either histofluorescence or immunohistochemistry using an antibody to dopamine\u2010beta\u2010hydroxylase. Symmetrical sites of the frontal cortex in both hemispheres were pretreated with 6\u2010hydroxydopamine (6\u2010OHDA). Then, the same cortical site of one hemisphere was infused with DMI by means of osmotic minipumps for more than 2 weeks, while the corresponding cortical site of the other hemisphere was infused with DMI plus MEP or BPB. It was found that the PLA2 inhibitors could attenuate the DMI\u2010induced regeneration of noradrenergic axons. Thus, if axonal retraction or degeneration of brain noradrenergic neurons is involved in the pathogenesis of clinical depression, elucidating the malfunction of the PLA2 systems may provide substantial evidence to aid in our understanding of the cause of depression at the molecular level. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.1070290305","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T17:02:57Z","timestamp":1109178177000},"page":"204-210","source":"Crossref","is-referenced-by-count":11,"title":["Effects of phospholipase A2 inhibitors on the antidepressant\u2010induced axonal regeneration of noradrenergic locus coeruleus neurons"],"prefix":"10.1002","volume":"29","author":[{"given":"Shoji","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(77)90016-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/268455a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb22598.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01730060001001"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870307"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870308"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90282-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1983.63.3.844"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90175-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/2041318a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90274-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6157192"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0026-895X(25)10783-9","article-title":"Adenylate cyclase\u2010coupled beta adrenergic receptors: Effect of membrane lipid\u2010perturbing agents on receptor binding and enzyme stimulation by catecholamines","volume":"12","author":"Limbird L. 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