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The relative repartition of these antigens in four cellular compartments of <jats:italic>Toxoplasma<\/jats:italic> (membrane complex, apical area, rhoptries, and dense granules) was quantitatively evaluated. Rhoptry antigens mainly react positively with IgA. Membrane, submenbrane area (membrane complex), and rhoptry antigens are immunodominant for IgA and IgM. Apical area antigens are recognized by IgM two times more than IgG and IgA. IgE recognized only rhoptry antigens.<\/jats:p><jats:p>The localization of pathogenetically antigenic components and their identification by the immune system appeared to be of importance for selection of immunodominant or recombinant antigens. Such localization would improve laboratory diagnosis of serious congenital toxoplasmosis or in immunocompromised patients with toxoplasmic complications after cyst reactivation. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.1070290309","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T17:02:57Z","timestamp":1109178177000},"page":"231-239","source":"Crossref","is-referenced-by-count":5,"title":["Subcellular localization and quantitative analysis of <i>Toxoplasma gondii<\/i> target antigens of specific immunoglobulins G, M, A, and E"],"prefix":"10.1002","volume":"29","author":[{"given":"E.","family":"Kumolosasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bonhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lepan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Foudrinier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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