{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:22Z","timestamp":1788871822414,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,6,5]],"date-time":"2001-06-05T00:00:00Z","timestamp":991699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutsche Krebshilfe, Bonn, Germany","award":["70-225 I"],"award-info":[{"award-number":["70-225 I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp;amp; Technique"],"published-print":{"date-parts":[[2001,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Normal gastric mucosa is devoid of lymphoid cells. Any increase of lymphocytes suggests chronic inflammation. Infection with\n                    <jats:italic>Helicobacter pylori (Hp)<\/jats:italic>\n                    is the major cause for nonautoimmune chronic gastritis and induces a mixed cellular response resulting in an acquired lymphoid tissue, or MALT (mucosa\u2010associated lymphoid tissue).\n                    <jats:italic>Hp<\/jats:italic>\n                    has also been implicated in the genesis of gastric MALT\u2010lymphoma. Polymerase chain reaction\u2010based assays to detect the expansion of monoclonal B\u2010cells have also been used to corroborate the diagnosis. In a considerable number of cases monoclonal B\u2010cells remain detectable in follow\u2010up biopsies, with the lymphoma being in complete histological remission. The clinical relevance of this finding is not clear yet. However, there also exist different reports that monoclonal B\u2010cells can be found in gastric biopsies of patients with neither a histological sign nor a present or past history of lymphoma. In the light of these findings we address the question whether B\u2010cell monoclonality can be seen as a premalignant condition in chronic gastritis and conclude that as of now the relevance of the finding of B\u2010cell monoclonality remains unclear. As of now the only and gold standard for the diagnosis of gastric MALT\u2010lymphoma is histopathology. Microsc. Res. Tech. 53:414\u2013418, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jemt.1110","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:26:02Z","timestamp":1030296362000},"page":"414-418","source":"Crossref","is-referenced-by-count":3,"title":["Are lymphocytic monoclonality and immunoglobulin heavy chain (IgH) rearrangement premalignant conditions in chronic gastritis?"],"prefix":"10.1002","volume":"53","author":[{"given":"Thomas","family":"W\u00fcndisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thiede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Alpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,6,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00628.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90214-2"},{"key":"e_1_2_1_4_1","first-page":"178b","article-title":"Continuous remission in patients with low grade B\u2010cell lymphoma of the mucosa associated lymphoid tissue (MALT) after Helicobacter pylori eradication","volume":"19","author":"Alpen B","year":"2000","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003130299105070"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199609)180:1<26::AID-PATH681>3.0.CO;2-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.2.593"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90145-3"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90446-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169508100603"},{"key":"e_1_2_1_13_1","first-page":"794","article-title":"Comparison of different polymerase chain reaction based approaches for clonality assessment of immunoglobulin heavy\u2010chain gene rearrangements in B\u2010cell neoplasia","volume":"12","author":"Derksen P","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.6.493"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.9.832"},{"key":"e_1_2_1_17_1","first-page":"885","article-title":"The differential diagnosis of early gastric mucosa associated lymphoma: polymerase chain reaction and paraffin section immunophenotyping","volume":"12","author":"El\u2010Zimaity HMT","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000315)48:6<321::AID-JEMT2>3.0.CO;2-U"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.5.311"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000040974"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90235-9"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609004870"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90071-4"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<122::AID-PATH486>3.0.CO;2-D"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.11.s1.5.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.7.624"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1349::AID-CNCR19>3.0.CO;2-1"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058387"},{"key":"e_1_2_1_30_1","first-page":"41","article-title":"Treatment of low grade gastric MALT\u2010lymphoma with Helicobacter pylori eradication. 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