{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:48:19Z","timestamp":1791726499213,"version":"4.3.4"},"reference-count":187,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T00:00:00Z","timestamp":1201132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Four decades have passed since the first discovery of collagen IV by Kefalides in 1966. Since then collagen IV has been investigated extensively by a large number of research laboratories around the world. Advances in molecular genetics have resulted in identification of six evolutionary related mammalian genes encoding six different polypeptide chains of collagen IV. The genes are differentially expressed during the embryonic development, providing different tissues with specific collagen IV networks each having unique biochemical properties. Newly translated \u03b1\u2010chains interact and assemble in the endoplasmic reticulum in a chain\u2010specific fashion and form unique heterotrimers. Unlike most collagens, type IV collagen is an exclusive member of the basement membranes and through a complex inter\u2010 and intramolecular interactions form supramolecular networks that influence cell adhesion, migration, and differentiation. Collagen IV is directly involved in a number of genetic and acquired disease such as Alport's and Goodpasture's syndromes. Recent discoveries have also highlighted a new and direct role for collagen IV in the development of rare genetic diseases such as cerebral hemorrhage and porencephaly in infants and hemorrhagic stroke in adults. Years of intensive investigations have resulted in a vast body of information about the structure, function, and biology of collagen IV. In this review article, we will summarize essential findings on the structural and functional relationships of different collagen IV chains and their roles in health and disease. Microsc. Res. Tech., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.20564","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T14:17:35Z","timestamp":1201184255000},"page":"357-370","source":"Crossref","is-referenced-by-count":611,"title":["Mammalian collagen IV"],"prefix":"10.1002","volume":"71","author":[{"given":"Jamshid","family":"Khoshnoodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Pedchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy G.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400416"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000123113.46672.68"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.3454.504"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.4.1569"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050215"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2349482"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"12090","DOI":"10.1016\/S0021-9258(19)50312-X","article-title":"The human mRNA encoding the Goodpasture antigen is alternatively spliced","volume":"268","author":"Bernal D","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.53"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.6030"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103690200"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207769200"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004569200"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.15.8529832"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(97)90030-5"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83686-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47648-X"},{"key":"e_1_2_1_18_1","first-page":"365","article-title":"Characterization of type IV collagen NC1 monomers and Goodpasture antigen in human renal basement membranes","volume":"115","author":"Butkowski RJ","year":"1990","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_19_1","first-page":"4796","article-title":"Type IV collagen\u2010mediated melanoma cell adhesion and migration: Involvement of multiple, distinct domains of the collagen molecule","volume":"49","author":"Chelberg MK","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041390209"},{"key":"e_1_2_1_21_1","first-page":"374","article-title":"Pathologic characteristics of hereditary nephritis","volume":"95","author":"Churg J","year":"1973","journal-title":"Arch Pathol"},{"key":"e_1_2_1_22_1","first-page":"2520","article-title":"Anti\u2010angiogenic cues from vascular basement membrane collagen","volume":"60","author":"Colorado PC","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000032419.13208.0C"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008956200"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199906)21:6<499::AID-BIES6>3.0.CO;2-D"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00132982"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.5.2.203"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14458.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90923-6"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb06168.x"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi980175"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.112.1.169"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.20.060191.001033"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200102"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/S0021-9258(17)42173-9","article-title":"Alternative splicing of the NC1 domain of the human \u03b13(IV) collagen gene. 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