{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:27:59Z","timestamp":1760660879716,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T00:00:00Z","timestamp":1269216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An expert system for differential diagnosis of thyroid pathology has been developed, in which the function of transforming qualitative signs of cell atypia into the quantitative form is realized. It based on the set of qualitative signs of cell atypia and works in the mode by the question\u2014answer principle. An expert system (software) contained the X\u2010matrix and six standard S\u2010matrices. The X\u2010matrix was designed for filling with the alternative answers yes\/no regarding the presence of cells with characteristic signs of atypia in the visual fields of a preparation. S\u2010matrices characterized the main forms of thyroid diseases, such as papillary and follicular cancer, follicular adenoma, autoimmune thyroiditis, nodular colloid and diffuse toxic goiter, by their set of yes\/no answers. The answers entered to the X\u2010matrix were compared with answers of the S\u2010matrix. Each element of each S\u2010matrix, besides the answers yes\/no, contained its weighting coefficient corresponding to a qualitative feature of a certain nosologic form. Weighting coefficient of each feature for every nosologic form was calculated by their frequency of occurrence in 30 visual fields. Comparison of X\u2010matrices with S\u2010matrices and verification of diagnosis according to the value of a diagnostic index with a percentage probability was performed in the automatic mode. Diagnostic index was determined by the sum of weighting coefficients of features with the coincident yes\/no answers, while comparing X\u2010matrix elements with the corresponding S\u2010matrix elements. The software displayed on the monitor is the list of nosologic forms in the order of decreasing the diagnostic index values. Microsc. Res. Tech. 73:1091\u20131100, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.20853","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T16:31:26Z","timestamp":1269275486000},"page":"1091-1100","source":"Crossref","is-referenced-by-count":1,"title":["Technology of creation of an expert system for diagnosing thyroid pathology based on a set of qualitative signs of cell atypia"],"prefix":"10.1002","volume":"73","author":[{"given":"Vladimir","family":"Kirillov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gladyshev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Demidchik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Quantitative Histopathology: the evolution of a scientific field","volume":"31","author":"Bartels PH","year":"2009","journal-title":"Analyt Quant Cytol Histol"},{"key":"e_1_2_6_3_1","first-page":"732","volume-title":"Atlas of clinical cytology","author":"Cardoco PL","year":"1976"},{"key":"e_1_2_6_4_1","first-page":"237","volume-title":"Diagnostic cytopathology","author":"Gray W","year":"2003"},{"key":"e_1_2_6_5_1","first-page":"513","volume-title":"Cytopathology. 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