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The aim of this work is to show the effects of noise on the myocardium and adrenal gland, through a careful review of the literature dealing with the peripheral effects of noise exposure in experimental and clinical studies. Noise induces adverse effects in human health, principally involving the cardiovascular and autonomic nervous systems, and the endocrine apparatus. Several factors in recreational environments potentially worsen the effects induced by loud noise. Among these, the intake of 3,4\u2010methylenedioxymethamphetamine (MDMA) is frequently associated with noise exposure in recreational situations, because of its high compliance within social and relaxation settings. For this reason, MDMA is defined as a club drug\u2014as its intake by young people often occurs in association with other factors, such as aggregation, high temperatures, and noise. It is known that self\u2010administration of MDMA by humans causes severe toxicity. In particular, the myocardium is affected early after MDMA intake\u2014resulting in tachycardia, hypertension, and arrhythmia. Furthermore, MDMA alters the activity of the adrenal glands by elevating catecholamines and corticosterone levels. This review shows that combining MDMA and loud noise exposure potentiates the effects that are produced by each single stimulant alone as seen in experimental animal models. The convergence of the effects of prolonged loud noise exposure and the consumption of MDMA on the same system might explain the sudden fatal events that happen in recreational situations. Microsc. Res. Tech., 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jemt.20971","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T16:02:25Z","timestamp":1292515345000},"page":"874-887","source":"Crossref","is-referenced-by-count":3,"title":["MDMA (ecstasy) enhances loud noise\u2010induced morphofunctional alterations in heart and adrenal gland"],"prefix":"10.1002","volume":"74","author":[{"given":"Federica","family":"Fulceri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Lenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Soldani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Bartalucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Paparelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"The extra\u2010auditory effects of noise and annoyance: An overview of research","volume":"19","author":"Abel SM","year":"1990","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(87)90181-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)91062-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0022-3565(25)12160-5","article-title":"Methamphetamine\u2010induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents","volume":"275","author":"Albers DS","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.6.560"},{"key":"e_1_2_6_7_1","first-page":"199","article-title":"Stereological and functional investigations on isolated adrenocortical cells. 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