{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:32:59Z","timestamp":1760661179505,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microscopy Res &amp; Technique"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is known that pre\u2010eclampsia affects the structure of the umbilical cord including changes in diameter and wall thickness. In this work, the morphological changes of umbilical cords associated with pre\u2010eclampsia were investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The SEM images showed the overall structural changes in the umbilical cord, and the AFM imaged the surface of the cord in the nanometer range. The amount of Wharton's jelly was reduced in the cords of pre\u2010eclampsia patients and it was holed along the boundary. Compared to a normal pregnancy, the surface of a pre\u2010eclampsia cord was relatively smooth. In all components (Wharton's jelly, veins, and arteries), the values for surface roughness, Sa (average value of the roughness), Sq (root mean square), and Sz (peak to peak value), were smaller than those of the control (<jats:italic>P<\/jats:italic> &lt; 0.05). Especially, the values for Sa of veins were \u223cfourfold less than those of the controls (<jats:italic>P<\/jats:italic> &lt; 0.05). In pre\u2010eclamptic cords, the amount of elastin in veins was increased while that of the artery was decreased. Microsc. Res. Tech. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jemt.22088","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T07:59:15Z","timestamp":1340179155000},"page":"1445-1451","source":"Crossref","is-referenced-by-count":0,"title":["Nanoscale imaging of morphological changes of umbilical cord in pre\u2010eclampsia"],"prefix":"10.1002","volume":"75","author":[{"given":"Kyung Sook","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ik","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Hyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun\u2010Kuk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0690477"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1993.21.6.491"},{"key":"e_1_2_6_4_1","first-page":"573","article-title":"Morphological changes in the utero\u2010placental bed in pregnancy hypertension","volume":"4","author":"Brosens JA","year":"1977","journal-title":"Clin Obstet Gynecol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90251-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-29838-X_17"},{"key":"e_1_2_6_7_1","first-page":"225","article-title":"Studi istologici sulle arteriole miometrali di la fuori della sede placentare nella EPH gestosi","volume":"4","author":"Cretti A","year":"1976","journal-title":"Patol Clin Ost"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00470-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02869910","article-title":"Collagen of the umbilical cord and its alteration in EPH\u2010gestosis (preeclampsia)","volume":"111","author":"Edward B","year":"1999","journal-title":"Proc Indian Acad Sci"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00470-X"},{"key":"e_1_2_6_11_1","first-page":"177","article-title":"Comparative morphological differences between umbilical cords from chronic hypertensive and preeclamptic pregnancies","volume":"56","author":"Inan S","year":"2002","journal-title":"Acta Med Okayama"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1987.tb00191.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2720787"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(98)01362-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014083"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13030176.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2002_3804"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2000.019"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600753133"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1997.16.10.691"}],"container-title":["Microscopy Research and Technique"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjemt.22088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jemt.22088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:51:06Z","timestamp":1760637066000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jemt.22088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,20]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/jemt.22088"],"URL":"https:\/\/doi.org\/10.1002\/jemt.22088","archive":["Portico"],"relation":{},"ISSN":["1059-910X","1097-0029"],"issn-type":[{"type":"print","value":"1059-910X"},{"type":"electronic","value":"1097-0029"}],"subject":[],"published":{"date-parts":[[2012,6,20]]}}}